Movement
Crossroad
Research theme: Neuromodulation
Clinical pillar: Movement
- Adaptive deep brain stimulation based on experience sampling methodology combined with peripheral wearable sensors.
- Mechanistic studies to unravel the pathophysiological basis behind the effects and side effects of neuro-modulation.
- Investigating novel targets and indications for neuro-modulation.
- Exploring new technologies to apply network and symptom-specific neuro-modulation.
Unique contributions and highlights
- Funded research line (Guy Peeters fonds, NFU, Weijerhorst, Abbott, Hersenstichting, ISAO, VENI, CHDI, Prosensa BV).
- Adaptive DBS using external feedback loop.
- Investigating circuitopathy in post-mortem Parkinson’s Disease (PD) brains using ultrahigh field (9.4T) MR imaging.
- Exploring the working mechanisms of DBS in PD using cell-specific viral tool, DREADD and optogenetic techniques.
- Wireless microneuromodulation in PD using magnetic nanoparticles.
- First group to explore sensor-ESM combination in Parkinson’s disease.
- First publications in Movement Disorders, Nature partner journal on Parkinson’s Disease, and Journal of Medical Internet Research.
Pieter Kubben
Staff involved in this crossroad
- Pieter Kubben
- Christian Herff
- Mark Janssen
- Mark Kuijf
- Annelien Duits
- Sarah Hescham
- Ali Jahanshahi
- Yasin Temel
- Albert Leentjens
- David Linden
- Dorothee Horstkötter
Departments:
- Neurology / Clinical Neurophysiology
- Neurosurgery
- Psychiatry & Neuropsychology