Launched in 2015, the Maastricht Centre for Systems Biology (MaCSBio) aims to develop a set of computational and mathematical models, applicable in science and clinic, that will advance our understanding of biological systems, and predict progression and treatment of complex diseases over time.
Technology is advancing fast. It gives us insights in the human body on both a large and miniscule scale. We can peek into the brain, without opening the skull. Our heartbeat can be measured using an app on our iPhone. The entire human genome is available as one large roadmap, and more and more knowledge about molecules in health and disease becomes available every day.
What if all of the available human data could be combined and deciphered by computers to create a “virtual physiological human”? Welcome to the world of Systems Biology.
MaCSBio is a joint initiative of the Faculty of Psychology and Neuroscience, Faculty of Health, Medicine and Life Science and the Faculty of Science and Engineering. To achieve scientific breakthroughs that could not be achieved in individual labs, the centre brings together the expertise of physicians, biologists, mathematicians and computer scientists.
Despite great technological advances in phenotyping, -omics and (noninvasive) imaging techniques, human biological data sets are often incomplete. Therefore, experts at MaCSBio use and further develop a broad range of innovative complex data analysis techniques, and mathematical and computational models and theories. This empowers scientists to effectively obtain new information from human biological and clinical data sets.
MaCSBio is committed to collaborate beyond its borders to share knowledge and know-how with the wider community, both at Maastricht University, but also internationally. This is achieved through a membership model with different levels of involvement, support and sharing. Send an email to our secretariat to connect with the experts today.
MaCSBio is fostering an environment of open and shared knowledge by actively seeking collaboration, organizing peer-to-peer learning and networking activities, early involvement of bachelor- and master students through teaching and internships, and postgraduate education. Interested in what your peers are doing in the field of Systems Biology? Get involved through the UM/MUMC+ Systems Biology Knowledge platform.
The framework of this research allows tissue cell type composition to emerge as a potential marker measuring homeostasis that can be utilized in prospective studies in regenerative medicine.
Scientists of Maastricht UMC+ and Maastricht University are closely involved in describing the molecular mechanism of the coronavirus.
Former PhD student Samar H.K. Tareen has successfully defended his thesis entitled 'Modelling molecular processes in weight loss: Regulation of metabolic flexibility'.
MaCSBio strives to perform cutting edge research in areas that are highly relevant for society. Research projects at MaCSBio are arranged into two main research lines:
Teaching takes place in the two-year master's programme Systems Biology, which combines theory and practical skills necessary for unraveling the complex interplay between biological systems.
The unique merge of disciplines such as biology, computer science and applied mathematics, will enable you to translate and integrate large datasets into biologically relevant information and prepare you for developing novel strategies to address scientific challenges.
“In many ways we are very different from other research institutes in biomedical and neurosciences. Our job is to extract meaningful information from large and complex biological datasets, generated mostly by our collaborators, with statistical and mathematical multiscale models.”
The Maastricht Centre for Systems Biology (MaCSBio) is a joint initiative of the Faculty of Science and Engineering (FSE) and the Faculty of Psychology and Neuroscience (FPN).
The centre’s primary aim is to facilitate the integration of biological data coming from several empirical domains using mathematical multi-scale modelling approaches.
The Maastricht Centre for Systems Biology (MaCSBio) has been founded with support of the Province of Limburg.