Research institutes

Maastricht MultiModal Molecular Imaging Institute

The Maastricht MultiModal Molecular Imaging Institute (M4I) is a state-of-the art molecular imaging institute that brings together a powerful palette of high-end, innovative imaging technologies. The mission of the institute is to perform fundamental, instrumentation and applied studies in molecular imaging as a part of a translational, synergistic, interdisciplinary research programme. M4I aims to be a leading international molecular imaging center relevant for science, education, economy and society.  The institute aspires to generate a high-end research environment and a unique knowledge infrastructure, attractive to top researchers from all over the world.

Two M4I Divisions

M4I | Division of Nanoscopy
Strives for greater insight into the 3D form of cell proteins, paving the way for developing more effective treatments for diseases such as cancer and tuberculosis while gaining better understanding of how protein complexes manage healthy and diseased cells, allowing drugs and vaccines to work more effectively.
 Go to division of Nanoscopy

M4I | Division of Imaging
Mass Spectrometry

Developing and applying state-of-the-art mass spectrometry based molecular imaging approaches for nanomedicine and biomedical research, including mass spectrometry as a diagnostic and prognostic tool for personalized medicine in oncology, neurology and cardiovascular medicine.  Go to division of IMS


The M4I Division of Nanoscopy investigates cell structures at a macromolecular level. Inside cells, proteins work together in complex structures and are responsible for virtually all processes in the human body, including diseases such as cancer. To understand the working mechanisms of protein complexes, three-dimensional imaging of normal and disease-causing protein complexes is essential. This could ultimately lead to more effective treatments, but also to vaccines against diseases such as tuberculosis.

The M4I Division of Imaging Mass Spectrometry is one of the world leaders in high resolution molecular imaging of biological surfaces. The division targets the development and application of state-of-the-art mass spectrometry based molecular imaging approaches for biomedical cellular and tissue research. Main research aim for the coming years is to develop and apply mass spectrometry as a diagnostic and prognostic tool for personalized medicine.


M4I’s scientists will be involved in teaching at a bachelor's, master's and PhD level, within the University College Maastricht, the Maastricht Science Programme and various programmes within the Faculty of Health, Medicine and Life Sciences.

Access to facilities

Requests to access the Nanoscopy or Imaging Mass Spectrometry facilities of M4I can be specified using the 'Access to facilities'-contact form. The lab manager of the requested facility will evaluate your request.


  • MSI symposium November 2017

    First workshop on Mass Spectrometry Imaging organised by M4i

    Friday, December 8, 2017

    From November 13-17th, 2017 M4i organised its first workshop dedicated to Mass Spectrometry Imaging (MSI). 

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  • The organising committe of OurCon V: Florian Barré (UM), Alina Astefanei (UvA), Irena Dapic (UvA), Philippe Saudemont (UdL), Brenda Bakker (UT), Lieke Lamont (UM), Pieter Kooijman (UM)

    International MSI conference OurCon organised by M4i

    Friday, November 10, 2017

    Three PhD students from Maastricht University's M4I took the lead in bringing the fifth edition of the OurCon mass spectrometry imaging (MSI) to the Netherlands.

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  • Lipiden MSI

    M4i research published in the Proceedings of the National Academy of Sciences (PNAS)

    Tuesday, November 7, 2017

    Research into the influence of lipids on the severity of a bacterial infection in a mammalian host published in PNAS.

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  • M4i hosts Mass Spectrometry Imaging workshop

    Tuesday, October 31, 2017

    M4i organizes its first workshop on Mass Spectrometry Imaging in Maastricht on November 13-17th, 2017.

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  • Ron Heeren in Analytical Scientist Power List 2017

    Monday, October 23, 2017

    Ron Heeren ranks #6 in the category 'Mass Spectrometrists' of the Analytical Scientist Power List 2017 

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  • Protein accumulation mapped for Alzheimer’s

    Monday, September 11, 2017

    Dankzij de Maastrichtse cryo-elektronenmicroscoop konden onderzoekers de moleculaire structuur in kaart brengen van het Beta-amyloïde eiwit, dat een rol speelt in de Ziekte van Alzheimer.

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  • Lieke Lamont receives poster prize

    MSACL-Poster prize for M4i researcher

    Monday, February 13, 2017

    Lieke Lamont, PhD candidate at the M4i division of Imaging Mass Spectrometry, was awarded a prize for her poster presentation at the 9th Conference on Mass Spectrometry Applications to the Clinical Lab.

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  • 3D imaging MS shows surface functionalization

    Monday, February 13, 2017

    Researchers from M4I and the TU/e (Technische Universiteit Eindhoven) have studied the three dimensional make up of surface functionalized supramolecular polymeric systems. The results of this collaborative project have been published in the leading international materials science journal “Advanced Materials” on february 5th, 2017. 

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  • phd IMS_Martijn Arts

    International Medical Postgraduate Conference presentation prize for Martijn Arts

    Tuesday, December 6, 2016

    Martijn Arts, PhD candidate at the department of General Surgery and the M4I division of Imaging Mass Spectrometry, was awarded the second prize for his talk at the 13th International Medical Postgraduate Conference - IMPC 2016 - .

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  • Official openings MERLN and M4I

    Wednesday, October 26, 2016

    On 8, 9 and 10 September the LINK Institutes MERLN and M4I held their official openings in the AINSI in Maastricht. 

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New M4I office wing

A new M4I office wing with the same open and transparent look and feel will be realised now. Based on C.O.R.E. collaborative open research education. C.O.R.E. requires a transparent and open environment for both laboratories and offices. M4I has invested heavily in an innovative and open environment for collaborative research. Research and office space is shared by scientist from very different backgrounds and disciplines, ranging from the fundamental sciences, technology and engineering as well as clinicians. In line with the CORE philosophy of Maastricht University the infrastructure is primed for researchers to cross the boundaries of their own disciplines and stimulate each other to excel in translational imaging science.

M4I office wing