CellFate 2 high

Niet ge- definieerd

Research line 1

Cell Biology - Inspired Tissue Engineering (cBITE)

Led by: Jan de Boer – Profile page

Research at cBITE is dedicated to understanding and applying basic cell biology principles in the field of biomedical engineering, in particular in the regeneration of bone tissue. The research program is characterized by a holistic approach to both discovery and application, aiming at combining high throughput technologies, computational modeling and experimental cell biology to streamline the wealth of biological knowledge to real clinical applications. For more information please visit the cBITE website.

The embedding of cBITE within MERLN is necessary to fulfill cBITE’s motto: “Where cell biology meets engineering”.

Our four main objectives are to:

  • become a center of expertise on high throughput screening of biomaterials
  • develop an educational program in which both the engineering and biological principles of regenerative medicine are taught
  • facilitate clinical application of technology in the field of regenerative medicine
  • play a pro-active role in shaping the future of MERLN

C2C12 Cell attachment movie

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Research line 2

Instructive Biomaterials Engineering (IBE)

Led by: Pamela Habibović – Profile page

Research at IBE is inspired and driven by materials science and engineering. The group aims at developing “smart”, instructive synthetic biomaterials for tissue and organ regeneration, with focus on inorganic materials for regeneration of connective tissue.

IBE's main objectives are:

  • the design and fabrication of biomaterials for regenerative medicine with closely controlled properties, by combining different material types and fabrication technologies
  • fundamental study of biological mechanisms behind interactions of biomaterials and cells/tissues, with the aim of designing and developing novel instructive biomaterials.
  • application of bioinorganics as synthetic “growth factors”
  • biomineralization
  • the development of screening platforms (e.g. based on microfluidics) to increase throughput of screening interactions of materials with the biological
    environment and rate at which new biomaterials are developed

Research Highlights

  • Engineering of calcium phosphate ceramics to be used as instructive biomaterials in regeneration of hard tissue and the use of bioinorganics as alternative synthetic “growth factors”.
  • Patterning of bioceramics to study their interactions with biological systems in a controlled manner.
  • Application of fundamental knowledge on biomineralization to develop improved strategies for regeneration of bone and bone-to-soft tissue interfaces.

3DHTS 11 07 2011

Niet ge- definieerd

Research line 3

Complex Tissue Regeneration (CTR)

Led by: Clemens van Blitterswijk – Profile page

At CTR, advanced macro, micro and nanobiofabrication technologies are developed and combined with fundamental knowledge of biology and materials chemistry towards the design of complex tissues and organs. With an emphasis on high-throughput approaches, potential applications of such constructs include stem cell research, developmental biology, cancer research, pharmaceutical or toxicological screening, tissue regeneration and bioartificial organs.

The technological bases for the fabrication of such constructs, ranging from bioprinting to advanced microwell arrays, are:

  • additive manufacturing technologies for building functional 3D scaffolds, such as 3D fiber deposition
  • advanced electrospinning technologies for generating extracellular matrix-like fibrous meshes
  • fabrication of highly functional film-based biomedical microdevices by micro and nanoscale 3D forming and superimposed patterned surface and bulk modification of thin polymer films
  • engineering of artificial cellular microenvironments and of in vitro 3D tissue and organ analogues using the aforementioned 3D film micro- and nanotechnologies
  • lithography for multiscale hierarchical 3D substrates, e.g. 3D nanoimprint, 3D deep UV or 3D X-ray lithography
  • bottom-up tissue engineering based on micro and nanoengineered objects as instructive microscaffolds
  • scaffold-free, self-assembled 3D tissues/organ spheroids
  • dynamic and responsive polymeric and supramolecular materials for the control and influence of cellular response

MERLN research centres around the following research lines

  • Research line 1

    Cell Biology - Inspired Tissue Engineering (cBITE)

    Dit is er niet
  • Research line 2

    Instructive Biomaterials Engineering (IBE)

    Dit is er niet
  • Research line 3

    Complex Tissue Regeneration (CTR)

    Dit is er niet