Movement

• Adaptive deep brain stimulation based on experience sampling methodology combined with peripheral wearable sensors.
• Mechanistic studies to unravel the pathophysiological basis behind the effects and side effects of neuro-modulation.
• Investigating novel targets and indications for neuro-modulation.
• Exploring new technologies to apply network and symptom-specific neuro-modulation.

Unique contributions and highlights

• Funded research line (Guy Peeters fonds, NFU, Weijerhorst, Abbott, Hersenstichting, ISAO, VENI, CHDI, Prosensa BV).
• Adaptive DBS using external feedback loop.
• Investigating circuitopathy in post-mortem Parkinson’s Disease (PD) brains using ultrahigh field (9.4T) MR imaging.
• Exploring the working mechanisms of DBS in PD using cell-specific viral tool, DREADD and optogenetic techniques.
• Wireless microneuromodulation in PD using magnetic nanoparticles.
• First group to explore sensor-ESM combination in Parkinson’s disease.
• First publications in Movement Disorders, Nature partner journal on Parkinson’s Disease, and Journal of Medical Internet Research.