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P.J.J. van Gorp, BSc

Key publications
Wouters, K., van Gorp, P. J. J., Bieghs, V., Gijbels, M. J., Duimel, H., Lutjohann, D., Kerksiek, A., van Kruchten, R., Maeda, N., Staels, B., van Bilsen, M., Sverdlov, R., & Hofker, M. H. (2008). Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis. Hepatology, 48(2), 474-486. https://doi.org/10.1002/hep.22363
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Recent publications
  • Reesink, K. D., Hendrikx, T., van Gorp, P. J., Hoeks, A. P., & Shiri-Sverdlov, R. (2018). Ultrasonic Perfluorohexane-Loaded Monocyte Imaging Toward a Minimally Invasive Technique for Selective Detection of Liver Inflammation in Fatty Liver Disease. Journal of Ultrasound in Medicine, 37(4), 921-933. https://doi.org/10.1002/jum.14432
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  • Houben, T., Oligschlaeger, Y., Hendrikx, T., Bitorina, A. V., Walenbergh, S. M. A., van Gorp, P. J., Gijbels, M. J. J., Friedrichs, S., Plat, J., Schaap, F. G., Luetjohann, D., Hofker, M. H., & Shiri-Sverdlov, R. (2017). Cathepsin D regulates lipid metabolism in murine steatohepatitis. Scientific Reports, 7(1), Article 3494. https://doi.org/10.1038/s41598-017-03796-5
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  • Walenbergh, S. M. A., Houben, T., Rensen, S. S., Bieghs, V., Hendrikx, T., van Gorp, P. J., Oligschläger, Y., Jeurissen, M. L. J., Gijbels, M. J. J., Buurman, W. A., Vreugdenhil, A. C. E., Greve, J. W. M., Plat, J., Hofker, M. H., Kalhan, S., Pihlajamaki, J., Lindsey, P., Koek, G. H., & Shiri-Sverdlov, R. (2016). Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention. Scientific Reports, 6, Article 38278. https://doi.org/10.1038/srep38278
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  • Jeurissen, M. L. J., Walenbergh, S. M. A., Houben, T., Gijbels, M. J. J., Li, J., Hendrikx, T., Oligschläger, Y., van Gorp, P. J., Binder, C. J., Donners, M. M. P. C., & Shiri-Sverdlov, R. (2016). Prevention of oxLDL uptake leads to decreased atherosclerosis in hematopoietic NPC1-deficient Ldlr(-/-) mice. Atherosclerosis, 255, 59-65. https://doi.org/10.1016/j.atherosclerosis.2016.10.038
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  • Jeurissen, M. L. J., Walenbergh, S. M. A., Houben, T., Hendrikx, T., Li, J., Oligschläger, Y., van Gorp, P. J., Gijbels, M. J. J., Bitorina, A., Nessel, I., Radtke, F., Vooijs, M., Theys, J., & Shiri-Sverdlov, R. (2016). Myeloid DLL4 Does Not Contribute to the Pathogenesis of Non-Alcoholic Steatohepatitis in LdIr(-/-) Mice. PLOS ONE, 11(11), Article e0167199. https://doi.org/10.1371/journal.pone.0167199
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  • Li, J., Chanda, D., van Gorp, P., Jeurissen, M. L. J., Houben, T., Walenbergh, S. M. A., Debets, J., Oligschläger, Y., Gijbels, M. J. J., Neumann, D., & Shiri-Sverdlov, R. (2016). Macrophage Stimulating Protein Enhances Hepatic Inflammation in alpha NASH Model. PLOS ONE, 11(9), Article e0163843. https://doi.org/10.1371/journal.pone.0163843
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  • Walenbergh, S. M., Houben, T., Hendrikx, T., Jeurissen, M. L., van Gorp, P. J. J., Vaes, N., Olde Damink, S. W. M., Verheyen, F., Koek, G. H., Lutjohann, D., Grebe, A., Latz, E., & Shiri-Sverdlov, R. (2015). Weekly Treatment of 2-Hydroxypropyl-beta-cyclodextrin Improves Intracellular Cholesterol Levels in LDL Receptor Knockout Mice. International journal of molecular sciences, 16(9), 21056-21069. https://doi.org/10.3390/ijms160921056
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  • Hendrikx, T., Jeurissen, M. L. J., Bieghs, V., Walenbergh, S. M. A., van Gorp, P. J., Verheyen, F., Houben, T., Guichot, Y. D., Gijbels, M. J., Leitersdorf, E., Hofker, M. H., Luetjohann, D., & Shiri-Sverdlov, R. (2015). Hematopoietic overexpression of Cyp27a1 reduces hepatic inflammation independently of 27-hydroxycholesterol levels in Ldlr(-/-) mice. Journal of Hepatology, 62(2), 430-436. https://doi.org/10.1016/j.jhep.2014.09.027
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  • Hendrikx, T., Jeurissen, M. L. J., van Gorp, P. J., Gijbels, M. J., Walenbergh, S. M. A., Houben, T., van Gorp, R., Pottgens, C. C., Stienstra, R., Netea, M. G., Hofker, M., Donners, M. M., & Shiri-Sverdlov, R. (2015). Bone marrow-specific caspase-1/11 deficiency inhibits atherosclerosis development in Ldlr(-/-) mice. FEBS Journal, 282(12), 2327-2338. https://doi.org/10.1111/febs.13279
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  • Walenbergh, S. M., Houben, T., Hendrikx, T., Jeurissen, M. L. J., van Gorp, P. J., Vreugdenhil, A. C., Adriaanse, M., Buurman, W., Hofker, M., Mosca, A., Lindsey, P. J., Alisi, A., Liccardo, D., Panera, N., Koek, G. H., Nobili, V., & Shiri-Sverdlov, R. (2015). Plasma cathepsin d levels: a novel tool to predict pediatric hepatic inflammation. American Journal of Gastroenterology, 110(3), 462-470. https://doi.org/10.1038/ajg.2015.29
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