MaCSBio - MISI Calculator
The MISI Calculator allows for the calculation of the muscle insulin sensitivity index (MISI) on oral glucose tolerance test (OGTT) data using both the original method proposed by Abdul-Ghani et al. (2007) and also the modified cubic spline method proposed by O’Donovan et al. (in preparation).
The Muscle Insulin Sensitivity Index (MISI) was proposed by Abdul Ghani et al. (2007). MISI aims to quantify muscle specific insulin sensitivity using OGTT data and has been validated against comparison with the hyperinsulinemic euglycaemic clamp combined with a glucose tracer infusion.
Download the MISI Calculator
The Muscle Insulin Sensitivity Index (MISI)
MISI is calculated as dG/dt/I where dG/dt is the line of best fit from the peak of the glucose curve to the nadir and I is the mean insulin over the duration of the OGTT. MISI is built on the assumption that the decay in the glucose curve during an OGTT (dG/dt) is primarily due to the uptake of ingested glucose by the skeletal muscle as the raised insulin concentration will have inhibited endogenous glucose production.
A modified Muscle Insulin Sensitivity Index (modified MISI) was proposed by O’Donovan et al. (in preparation). It makes use of cubic splining to infer the full OGTT glucose and insulin curve from them measured data thereby improving prediction of the glucose peak and nadir while also accounting for unequal sampling schedules. MISI is then computed on the inferred glucose and insulin curves.
Shauna O'Donovan
PhD Candidate
"I wanted to go into a field of research which would involve mathematical modelling of a biological system, and for me the topics being investigated within the SYSTOPP project were particularly interesting as several members of my family have Type 2 Diabetes."