PhD conferral Ms Charlotte P.J. Talbot, MSc.
Supervisors: prof.dr.ir. R.P. Mensink, prof.dr. J. Plat
Keywords: cardiovascular disease, HDL, cholesterol efflux
"Cholesterol efflux as a measure of HDL functionality in humans: impact of genetics, diet and weight loss"
Cardiovascular disease (CVD) is one of the leading causes of death worldwide. Increasing the levels of the good cholesterol, namely HDL, is an attractive target for CVD prevention. However, this strategy failed to reduce CVD risk, while recent evidences suggest that increasing the HDL-mediated cholesterol efflux capacity is more protective. The research studies presented in this dissertation showed that cholesterol efflux is genetically determined. However, the dietary factors investigated, i.e. theobromine, a compound found in dark chocolate, and plant sterol and stanol, as well as weight loss were not associated with an improvement in HDL-mediated cholesterol efflux.
Also read
-
PhD Defence Emmanuel Tan Chee Peng
"Beyond Hogwarts and Sorting Hats: How a House System shapes medical student support"
10 Jun -
PhD Defence Mariia Denisova
"Co-construction of reliable knowledge, good care and profit-making: The ambivalent role of private clinics in Russian healthcare"
10 Jun -
PhD Defence Charlotte Merel Marije Peters
"Beyond The Red Lights: Understanding the STI/HIV burden and sexual healthcare needs of home-based and migrant sex workers"
11 Jun