Keywords: coronary artery disease, antithrombotic therapy, bleeding risk, laboratory testing

"Personalized antithrombotic treatment in high-risk patients with coronary artery disease"

This thesis focused on aspects in clinical care for high-risk patients with coronary artery disease on dual or triple antithrombotic therapy. In particular, the role of several laboratory tests in prediction and prevention of bleeding events in this patient group has been assessed. Part one of this thesis is based on the Maastricht cohort of 524 high-risk patients on dual or triple antithrombotic therapy after percutaneous coronary intervention (PCI). The value of several laboratory tests as well as genetic testing in prediction of bleeding events was investigated. The second part of this thesis focuses on treatment strategies in patients with coronary artery disease. A strategy of dual antithrombotic therapy has been compared to a strategy with triple therapy in patients with both a recent PCI and atrial fibrillation. Both the occurrence of bleeding events and major adverse cardiovascular events were compared between both groups.  

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