Systems BioMedicine
Projects within this theme aim to increase our understanding of chronic diseases related to metabolism, such as obesity, diabetes, heart failure, kidney failure, ageing and immune function, and to develop new, biology-based, personalised approaches to prevent and treat them.
Biological expertise on metabolism, gene regulation, pharmacology and chronic diseases is combined with a broad spectrum of modelling approaches such as dynamic models, network- and pathway biology, and machine learning/AI and statistical inference.
People
- Prof. Ilja Arts - digital twins, personalised health, molecular epidemiology, biomarkers, obesity, diabetes, metabolomics, gut microbiota
- Prof. Aurélie Carlier – dynamic modelling (ODEs, PDEs, agent-based), PBPK modeling, fibrosis, chronic kidney disease, sex differences
- Michiel Adriaens - multi-omics, metabolic modelling, regulatory genomics, heart failure, personalised nutrition, machine learning
- Marian Breuer - metabolic modelling, metabolic networks, omics data integration, ageing
- Martina Summer-Kutmon - Network biology, pathway modelling, bioinformatics, multi-omics data analysis, immunometabolism
Projects
Active projects
- EDI-MSK: Equitable musculoskeletal health driven by inclusive models (MSCA Doctoral Network; 01/2027 – 12/2030)
- iDOSE: Next-generation in vitro–in silico platform to unravel sex differences in renal drug handling (NWO-Vidi; 04/2026-03/2030)
- PRECINUT
- PERSON study
- NGID – Next Generation Inflammatory Skin Diseases (NWA NWO consortium, 2023-2029)
- AUTOMATHIC: New methodologies for automated modeling of the dynamic behavior of large biological networks ( ERC STG; 12/2024 – 12/2029)
- BAK2theFuture: BioArtificial Kidney device consisting of living membranes for improved kidney replacement therapy (NWO-OTP; 09/2024 – 08/2028)
- DETOX: A combined computational-experimental approach to unravel drug-toxin interactions in chronic kidney disease (DKF Success Accelerator grant; October 2023-April 2028)
Modeling the Metabolic Diversity of the Brain’s Glial Cells (CSC, M. Breuer and R. Jolivet, 2023-2027)
- NUTRIOME – MSCA Doctoral Network (2023-2027)
post-COVID disease mechanisms (ZonMw, 2024-2026)
Completed projects
- SOPHIA – Stratification of Obese Phenotypes to Optimize Future Obesity Therapy (2020-2025)
- WikiPathways as a platform for COVID-19 pathway models (ZonMw, 2020-2023)
- MATRyOShka – Metabolic Adaptation, Transitions and Resilience in Overweight individualS - NWO Complexity in Health and Nutrition (2017-2023)
- Early life effects of human milk oligosaccharides and prebiotics on antibiotic-associated gut microbiota changes and health (CCC Carbobiotics, 2018-2023)
- PREVENTOMICS – Empowering consumers to PREVENT diet-related diseases through OMICS sciences (2018-2022)
Glucose control in relation to Mental And Physical Performance and well-beING (TiFN-TKI Agro & Food, 2017-2021)
Novel technologies to analyse multilevel high-dimensional time-series challenge test data (ZonMw, Enabling Technologies Hotels)
- Metabolic modelling of the loss of metabolic flexibility in the failing heart – NWO XS
Community initiatives