Are you looking for practical work experience in a young, international research institute? At MaCSBio we give you the opportunity to get more familiar with working on research projects in the field of systems biology whilst learning from experienced colleagues. During your internship you can be involved in a variety of activities such as data generation, data analysis and modeling. But you will also experience your strengths and challenges as a researcher in the field of systems biology.
Cell-type specific markers of cardiovascular disease: it’s in our blood?
We are living in the age of obesity. Obese individuals are at an increased risk of developing disease, including cardiovascular disease (CVD). At the Maastricht Centre for Systems Biology (MaCSBio), one of our aims is therefore to establish personalized risk profiles for CVD in the obese. The eventual goal is preventive medicine: identification of individuals that are at a higher risk, who can receive treatment before developing severe complications.
Predictive modeling of response to dietary intervention
Approximately 425 million people suffer from diabetes worldwide with an estimated 629 million to be affected by 2045 (International Diabetes Federation, 2017). Diabetes can lead to multiple acute and chronic complications resulting in a lower quality of life and higher early mortality rate when compared to healthy subjects. The development of type II diabetes mellitus (T2DM) is strongly linked to genetics, but also lifestyle factors, including obesity, diet and lack of physical activity.
An ultra-high field fMRI investigation of auditory learning
Hearing, understanding, and interacting with sounds is crucial in our everyday life. While seemingly straightforward, hearing is an extremely adaptive and flexible process. For example, in a noisy environment we can tune in to those sounds that are currently important to us, and we can learn to recognize the voice of a new friend. Recent invasive studies showed that this flexibility is accompanied by rapid and/or long-lasting changes in brain processing.
Learning and memory: From gene networks to brain activation patterns
In recent years, advances in non-invasive neuroimaging and genetics have created the possibility to collect large amounts of data in a manageable time period. The question remains whether all this data can help us to elucidate the functioning of the human brain, and to study the influence of genetics on brain processing.
Fusion and fission: the orchestra of mitochondrial dynamics
Mitochondrial processes particularly interesting in the context of learning are mitochondrial fusion, fission, transport and turnover, collectively called mitochondrial dynamics. Mitochondrial dynamics is crucial for maintaining a healthy mitochondrial pool and defects in this process have been associated with defects in neuronal development, plasticity and functioning. However, not all proteins involved in mitochondrial dynamics are known.
Functional characterization of mitochondrial DNA maintenance proteins
The discovery and functional characterization of novel components of mtDNA maintenance will improve our understanding of these processes in health and disease. Moreover, it will improve genetic diagnostic tests and open possibilities for designing therapeutic interventions, improving quality of life for patients with mitochondrial disorders.
Metabolism of the heart in health and disease
In this project, health-relevant features of metabolism in cardiomyocytes will be studied with metabolic modelling approaches. Many pathological conditions of the heart are known to have a metabolic component. However, while individual connections to metabolism have been studied, no systematic, comprehensive investigation of these complex connections has been carried out thus far.
Investigating the players of our defense system
Living cells are complex. The average human body consists of approximately 37 trillion cells each containing thousands of molecules that work together to enable the cell to carry out its specific function. In this project, you will specifically look at immune cells, the key players of our defense system.
No internships that fit your interest?
Are there no projects that fit your current interests, but are you still excited to work at MaCSBio? We encourage you to send in a message where you tell us what you would like to do and we will contact you about the opportunities at MaCSBio.
I study Health Sciences at Maastricht University, but I still have to complete two courses. These courses won’t start until February and during this gap I wanted to broaden my horizon and keep active with doing research.