Therapeutic Delivery of miR-148a Suppresses Ventricular Dilation in Heart Failure
In this study, group de Windt demonstrated that miR-148a expression changes dynamically in distinct subtypes of heart failure: while it is elevated in concentric hypertrophy, it decreased in dilated cardiomyopathy. The findings in this study provide evidence for the existence of separate molecular programs inducing distinct forms of myocardial remodeling.
Heart failure is preceded by ventricular remodeling, changes in left ventricular mass, and myocardial volume after alterations in loading conditions. Concentric hypertrophy arises after pressure overload, involves wall thickening, and forms a substrate for diastolic dysfunction. Eccentric hypertrophy develops in volume overload conditions and leads wall thinning, chamber dilation, and reduced ejection fraction. The molecular events underlying these distinct forms of cardiac remodeling are poorly understood.
Also read
-
MaaSec – The Netherlands' Only Active ACM Student Chapter captures the flag
In January, a group of Computer Science students at Maastricht University launched MaaSec, currently the only active ACM student chapter in the Netherlands. And in just a few months, they've already made a name for themselves; especially in the world of Capture the Flag (CTF) competitions.
-
Publication of the National Vision on Sustainable Carbon in the Chemical Industry
On April 22, the National Vision on Sustainable Carbon in the Chemical Industry was published for public consultation.
-
Municipality of Heerlen, Parkstad Urban Region and UM invest 6 million in collaboration
Heerlen grants a one-time contribution of €1,478,050 to Maastricht University as part of the Regio Deal application ‘Fundament onder UM-onderwijs in Heerlen’. This amount comes from the Fonds Economische Structuurversterking (FES). The funding will help establish university education facilities in...
