Smoking cessation drug has fewer side effects than initially believed

Varenicline does not cause depression or cardiac symptoms in smokers (MUMC+ news)


A commonly prescribed drug to aid in smoking cessation does not cause cardiac symptoms or depression, as previously believed. This according to a study of 150,000 smokers who used the medication to help them quit smoking. A team of researchers from Maastricht UMC+ and the universities of Dusseldorf, Edinburg and London researched the alleged side effects of the drug varenicline. Their research findings were published in the leading scientific journal The Lancet Respiratory Medicine.

Many people find it difficult to quit smoking due to the addictive properties of nicotine. The presence of this substance in cigarette smoke causes an intense and constant craving for a cigarette. Quitting suddenly has been linked to withdrawal symptoms, such as depression, insomnia, difficulty concentrating and restlessness. Certain medications can help people quit smoking. Varenicline, which mimics the effects of nicotine, is one of the most common and the most effective drugs. However, it was also believed to have potential side effects like depression and cardiac symptoms. According to the latest study, these claims are unfounded.

Safe and effective

The researchers compared data on 150,000 smokers who wanted to quit with the help of smoking cessation aids like nicotine gum, nicotine patches or varenicline. They researched the health effects of these treatments over a period of six months and found that varenicline did not increase the risk of cardiac arrest or depression compared to the other treatment options. 'The results prove that this is a safe drug to help people quit smoking,' says head researcher Professor Daniel Kotz, who is affiliated with the universities of Dusseldorf and Maastricht.

Withdrawal

'If you've been smoking for years and suddenly stop, this will naturally have an effect on your body,' says co-author Professor Onno van Schayck of Maastricht UMC+. 'Depression and cardiac symptoms are potential consequences of long-term smoking. This means they are not caused by medication and that drugs can be safely prescribed as a tool to help people quit smoking. It's important that people who plan to quit are aware of the effects this can have on their body and mind in the short and the long term.'

Also read

  • The Societal Impact Project

    The Societal Impact Project stimulates students’ autonomous motivation to work on societal relevant problems. One of the topics this year is vaping.

    societal impact project biomedical sciences
  • Vaccine promotion policies for COVID-19

    Two researchers from Maastricht University play a key role in translating research into vaccine policy recommendations for COVID-19: Timo Clemens, Associate Professor health policy and governance, and Inge van der Putten, Assistant Professor at the department of Health Services Research.

    Timo Clemens and Inge van der Putte
  • From Economics to Branding and Innovation: The journey of Patrick van Thiel

    Patrick van Thiel’s academic journey began in Rotterdam before he found his true calling at Maastricht University in 1989. Drawn by the Problem-Based Learning (PBL) system, he quickly excelled academically, earning 90 credits in just one year. However, it wasn’t until he discovered his passion for...

    Patrick V Thiel SBE Alumni