28 May 2021

Paper in Lancet Neurology

The Meta VCI Map consortium, coordinated by UMC Utrecht, aims to perform large-scale meta-analyses on strategic lesion locations, using lesion-symptom mapping. A pooled analysis of data on 2950 patients from 12 cohorts was performed, achieving a high lesion coverage of the brain of 86%. Infarcts in the left frontotemporal lobes, left thalamus, and right parietal lobe were strongly associated with post-stroke cognitive impairment. A ‘location impact score’ was derived that robustly predicted post-stroke cognitive impairment.