Double inaugural lecture in Maastricht
Paul Volders, a cardiologist at the Cardiovascular Centre of Maastricht UMC+, and Prof. Monika Stoll, a researcher with the University of Münster, have both recently been inaugurated as professors holding an endowed chair at Maastricht University. The remits of the two chairs complement one another: Genetic Cardiology (Volders) and Genetic Epidemiology and Statistical Genetics (Stoll).
Volders and Stoll carry out research into the genetic backgrounds of cardiovascular disease. A few years ago, Paul Volders detected a genetic disorder occurring in several interrelated families in South Limburg which can cause cardiac arrhythmia and even sudden cardiac death. His ongoing investigation into this disorder is called the ‘Worm Study’ after the river on the south-eastern border of Limburg. In the Worm Study, Volder focusses on the cardiological side of the story. Monika Stoll mainly investigates the causes of cardiovascular conditions on a molecular level.
Perfect study material
Stoll is also investigating the way in which the human body adapts evolutionarily to hereditary disorders. The Worm Study supplies perfect study material to this end. As a genetic epidemiologist, she benefits from the existence of a so-called founder mutation, i.e. a genetic disorder which occurs in several, interrelated families and which can be traced back to a single person, the founder. Many cardiovascular diseases (including the cardiac arrhythmias in the Worm Study) can currently be explained only to a small extent in terms of genetic variations, the ‘tip of the iceberg’ as it were. The largest part is below the surface of the water.
Divers in cold seawater
Stoll and Volders, looking at the same problem from different angles, hope to develop methods to prevent cardiovascular disorders by identifying the basis of a disorder at an early stage. Volders: ‘As the titles of our inaugural lectures indicate, we are in the process of exploring an iceberg of which the largest part is under water. For now, we are like divers in the cold seawater who try to estimate the size, composition and risks of the submerged ice. But with current cardiogenetic developments we will be able to shrink the base of the ice fast in individual cases. This may be bad for the sea level, but to patients and their family members it will bring important improvements in the prevention and treatment of serious heart problems, including sudden cardiac death.’
The two brand-new professors have been appointed to the CARIM School for Cardiovascular Diseases. The inaugural lecture of Volders is titled 'Below Icebergs' (Onder IJsbergen), while Prof. Stoll’s inaugural lecture is titled 'The tip of the Iceberg'.
Also read
-
This year, the total number of students at Maastricht University will probably still increase slightly to more than 23,000. Due to an estimated 3% decrease in the number of new students, this growth will level off. The ratio of Dutch to international students is also stabilising: among the new cohort, the proportion of Dutch students is increasing slightly. A large proportion of students still come from within Maastricht’s Euregion; over 50% of students come from within a 100-kilometre radius of Maastricht.
-
In the coming years, the Venlo municipality and Maastricht University (UM) will make additional investments in the city's academic research and education. The goals aim to create future-proof solutions for food and its production while being healthy for people, the environment, and the economy. This relies heavily on technological innovation.
-
When breast cancer has spread to lymph nodes in the armpit, extensive imaging studies are performed and tumour characteristics are determined prior to surgical removal. Research initiated at Maastricht UMC+ aims to clarify the extent to which an accurate assessment can be made of possible responses to chemotherapy prior to surgery. As a result, extensive surgery to the armpit may not always be required in the future. The KWF is subsidising the research with € 538,000.