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M.C.T. Verheijen

Research projects

EU 7th Framework Programme: HeCaToS Project, Hepatic and Cardiac Toxicity Systems 

CEFIC: R-ODAF, Omics Data Analysis Framework for Regulatory applications

Interreg: Memories (Herinneringen) Project

Key publications
Verheijen, M. (2019). Transcriptomics close to my heart: advanced models & methods for toxicogenomics research illustrated by anthracycline-induced cardiotoxicity. [Doctoral Thesis, Maastricht University]. ProefschriftMaken Maastricht. https://doi.org/10.26481/dis.20190517mv
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Recent publications
  • Soluyanova, P., Quintás, G., Pérez-Rubio, Á., Rienda, I., Moro, E., van Herwijnen, M., Verheijen, M., Caiment, F., Pérez-Rojas, J., Trullenque-Juan, R., Pareja, E., & Jover, R. (2024). The Development of a Non-Invasive Screening Method Based on Serum microRNAs to Quantify the Percentage of Liver Steatosis. Biomolecules, 14(11), Article 1423. https://doi.org/10.3390/biom14111423
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  • Bischoff, N. S., Breda, S. G., Briede, J. J., Elferink, I., van Herwijnen, M., Verheijen, M., van Bodegraven, A., Drenth-Brink, L., Peelen-Buijs, M., Sijm, D. T., & de Kok, T. M. (2024). Evaluating the effects of food additive E171 on colorectal cancer risk: a human dietary intervention study. Toxicology Letters, 399, S220-S220. https://doi.org/10.1016/j.toxlet.2024.07.541
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  • Kuligowski, J., Pérez-Rubio, Á., Moreno-Torres, M., Soluyanova, P., Pérez-Rojas, J., Rienda, I., Pérez-Guaita, D., Pareja, E., Trullenque-Juan, R., Castell, J. V., Verheijen, M., Caiment, F., Jover, R., & Quintás, G. (2024). Cluster-Partial Least Squares (c-PLS) regression analysis: Application to miRNA and metabolomic data. Analytica Chimica Acta, 1286, Article 342052. https://doi.org/10.1016/j.aca.2023.342052
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  • Verheijen, M., Sarkans, U., Wolski, W., Jennen, D., Caiment, F., Kleinjans, J., & HeCaToS Consortium (2022). Multi-omics HeCaToS dataset of repeated dose toxicity for cardiotoxic & hepatotoxic compounds. Scientific data, 9(1), Article 699. https://doi.org/10.1038/s41597-022-01825-1
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  • Wen, Q., Verheijen, M., Wittens, M. M. J., Czuryło, J., Engelborghs, S., Hauser, D., van Herwijnen, M. H. M., Lundh, T., Bergdahl, I. A., Kyrtopoulos, S. A., de Kok, T. M., Smeets, H. J. M., Briedé, J. J., & Krauskopf, J. (2022). Lead-exposure associated miRNAs in humans and Alzheimer's disease as potential biomarkers of the disease and disease processes. Scientific Reports, 12(1), Article 15966. https://doi.org/10.1038/s41598-022-20305-5
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  • Wen, Q., Verheijen, M., Wittens, M. M., Engelborghs, S., Bergdahl, I. A., Kyrtopoulos, S. A., De Kok, T. M., Smeets, H. M., Briede, J. J., & Krauskopf, J. (2022). Lead-exposure associated miRNAs in humans and Alzheimer's disease: Potential biomarkers of the disease and disease processes. Toxicology Letters, 368, S294-S294. https://doi.org/10.1016/j.toxlet.2022.07.769
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  • Verheijen, M. C. T., Meier, M. J., Asensio, J. O., Gant, T. W., Tong, W. D., Yauk, C. L., & Caiment, F. (2022). R-ODAF: Omics data analysis framework for regulatory application. Regulatory Toxicology and Pharmacology, 131, Article 105143. https://doi.org/10.1016/j.yrtph.2022.105143
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  • Verheijen, M. C. T., Krauskopf, J., Caiment, F., Nazaruk, M., Wen, Q. F., van Herwijnen, M. H. M., Hauser, D. A., Gajjar, M., Verfaillie, C., Vermeiren, Y., De Deyn, P. P., Wittens, M. M. J., Sieben, A., Engelborghs, S., Dejonckheere, W., Princen, K., Griffioen, G., Roggen, E. L., & Briedé, J. J. (2022). iPSC-derived cortical neurons to study sporadic Alzheimer disease: A transcriptome comparison with post-mortem brain samples. Toxicology Letters, 356, 89-99. https://doi.org/10.1016/j.toxlet.2021.12.009
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  • Ochoteco Asensio, J., Verheijen, M., & Caiment, F. (2022). Predicting missing proteomics values using machine learning: Filling the gap using transcriptomics and other biological features. Computational and Structural Biotechnology Journal, 20, 2057-2069. https://doi.org/10.1016/j.csbj.2022.04.017
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  • Nguyen, N., Souza, T., Verheijen, M. C. T., Gmuender, H., Selevsek, N., Schlapbach, R., Kleinjans, J., & Jennen, D. (2021). Translational Proteomics Analysis of Anthracycline-Induced Cardiotoxicity From Cardiac Microtissues to Human Heart Biopsies. Frontiers in Genetics, 12, Article 695625. https://doi.org/10.3389/fgene.2021.695625
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Other publications

Towards the development of an omics data analysis framework. 

https://doi.org/10.1016/j.yrtph.2020.104621