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G.G.H. van den Akker

Research projects

Current projects:

2025-present: CPBT Osteoarthritis and Reumatoid Arthritis Transition project (WP leader)

CPBT - Centrum voor Proefdiervrije Biomedische Translatie | Centre for Animal-Free Biomedical Translation

2023-present: ReumaNederland, protein translation (PI)

Dit gebeurt er in een gewricht met artrose | ReumaNederland

2021- present: OpZuyd Intellectuals (WP leader)

INTELLECTUALS - OPZuid 2021-2027

theinchip: an OPZuid Project

Previous projects:

2018-2022: William Hunter Revisited (post-doc)

William Hunter revisited: Activating intrinsic cartilage repair to restore joint homeostasis | NWO

2014-2018: UKRMP SmartStep (post-doc)

2009-2014: Biomedical Materials consortium IDIDAS (PhD student)

Key publications
  • van den Akker, G. G. H., Chabronova, A., Housmans, B. A. C., van der Vloet, L., Surtel, D. A. M., Cremers, A., Marchand, V., Motorin, Y., Caron, M. M. J., Peffers, M. J., & Welting, T. J. M. (2024). TGF-β2 Induces Ribosome Activity, Alters Ribosome Composition and Inhibits IRES-Mediated Translation in Chondrocytes. International Journal of Molecular Sciences, 25(9), Article 5031. https://doi.org/10.3390/ijms25095031
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  • Chabronova, A., van den Akker, G. G. H., Housmans, B. A. C., Caron, M. M. J., Cremers, A., Surtel, D. A. M., Wichapong, K., Peffers, M. M. J., van Rhijn, L. W., Marchand, V., Motorin, Y., & Welting, T. J. M. (2023). Ribosomal RNA-based epitranscriptomic regulation of chondrocyte translation and proteome in osteoarthritis. Osteoarthritis and Cartilage, 31(3), 374-385. https://doi.org/10.1016/j.joca.2022.12.010
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  • van den Akker, G. G. H., Steijns, J. S. J. J., Stassen, R. H. M. J., Wasilewski, G. B., Peeters, L. C. W., Wijnands, K. A. P., Schurgers, L. J., Caron, M. M. J., van Rhijn, L. L. W., & Welting, T. J. M. (2023). Development of a cyclic-inverso AHSG/Fetuin A-based peptide for inhibition of calcification in osteoarthritis. Osteoarthritis and Cartilage, 31(6), 727-740. https://doi.org/10.1016/j.joca.2022.11.007
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  • Stassen, R. H. M. J., van den Akker, G. G. H., Surtel, D. A. M., Housmans, B. A. C., Cremers, A., Caron, M. M. J., Smagul, A., Peffers, M. J., van Rhijn, L. W., & Welting, T. J. M. (2023). Unravelling the Basic Calcium Phosphate crystal-dependent chondrocyte protein secretome; a role for TGF-ß signaling. Osteoarthritis and Cartilage, 31(8), 1035-1046. https://doi.org/10.1016/j.joca.2023.02.079
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  • Housmans, B. A. C., Neefjes, M., Surtel, D. A. M., Vitík, M., Cremers, A., van Rhijn, L. W., van der Kraan, P. M., van den Akker, G. G. H., & Welting, T. J. M. (2022). Synovial fluid from end-stage osteoarthritis induces proliferation and fibrosis of articular chondrocytes via MAPK and RhoGTPase signaling. Osteoarthritis and Cartilage, 30(6), 862-874. https://doi.org/10.1016/j.joca.2021.12.015
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  • Neefjes, M., Housmans, B. A. C., van Beuningen, H. M., Vitters, E. L., van den Akker, G. G. H., Welting, T. J. M., van Caam, A. P. M., & van der Kraan, P. M. (2022). Prediction of the Effect of the Osteoarthritic Joint Microenvironment on Cartilage Repair. Tissue Engineering, 28(1-2), 27-37. https://doi.org/10.1089/ten.tea.2021.0051
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  • van den Akker, G. G. H., Surtel, D. A. M., Cremers, A., Rodrigues-Pinto, R., Richardson, S. M., Hoyland, J. A., van Rhijn, L. W., Welting, T. J. M., & Voncken, J. W. (2014). Novel immortal human cell lines reveal subpopulations in the nucleus pulposus. Arthritis Research & Therapy, 16(3), Article R135. https://doi.org/10.1186/ar4597
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  • Saapen, F., van den Akker, G. G. H., Caron, M. M. J., Prickaerts, P., Rofel, C., Dahlmans, V. E. H., Surtel, D. A. M., Paulis, Y., Schweizer, F., Welting, T. J. M., Eijssen, L. M., & Voncken, J. W. (2013). The Immediate Early Gene Product EGR1 and Polycomb Group Proteins Interact in Epigenetic Programming during Chondrogenesis. PLOS ONE, 8(3), Article 58083. https://doi.org/10.1371/journal.pone.0058083
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Recent publications
  • Gosselink, I. F., Leonhardt, P., Höppener, E. M., Smelt, R., Drittij, M. J., Davigo, M., van den Akker, G. G. H., Kooter, I. M., Welting, T. J. M., van Schooten, F. J., & Remels, A. H. V. (2025). Size- and polymer-dependent toxicity of amorphous environmentally relevant micro- and nanoplastics in human bronchial epithelial cells. Microplastics and Nanoplastics, 5(1), Article 19. https://doi.org/10.1186/s43591-025-00126-9
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  • Kibble, M. J., Ferreira, M. J. S., Usta, Y. H., van den Akker, G. G. H., Moxon, S. R., Baird, P., Hoyland, J. A., Domingos, M. A. N., & Richardson, S. M. (2025). Suspension bioprinted whole intervertebral disc analogues enable regional stiffness- and hypoxia-regulated matrix secretion by primary human nucleus pulposus and annulus fibrosus cells. Acta Biomaterialia, 200, 378-389. https://doi.org/10.1016/j.actbio.2025.05.015
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  • Neefjes, M., Housmans, B. A. C., Kaffa, C., Thielen, N. G. M., Joosten, L. A. B., van den Ende, C. H. M., Vitters, E. L., van den Akker, G. G. H., Welting, T. J. M., van Caam, A. P. M., & van der Kraan, P. M. (2025). Cell-integrated serum-induced signalling patterns can differentiate between hand and knee osteoarthritis patients. Rheumatology, 64(6), 3929-3937. https://doi.org/10.1093/rheumatology/keae555
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  • Stassen, R. H. M. J., van den Akker, G. G. H., Caron, M. M. J., Surtel, D. A. M., Cremers, A., van Rhijn, L. W., & Welting, T. J. M. (2025). TGF-ß Enhances Phosphate-Driven Calcification of Human OA Articular Chondrocytes. Calcified Tissue International, 116(1), Article 57. https://doi.org/10.1007/s00223-025-01365-x
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  • Niessink, T., Stassen, R. H. M. J., Kischkel, B., Vuscan, P., Emans, P. J., van den Akker, G. G. H., Janssen, M., Joosten, L. A. B., Otto, C., Welting, T. J. M., & Jansen, T. L. (2024). Discovery of calcite as a new pro-inflammatory calcium-containing crystal in human osteoarthritic synovial fluid. Osteoarthritis and Cartilage, 32(10), 1261-1272. https://doi.org/10.1016/j.joca.2024.05.004
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  • van den Akker, G. G. H., Chabronova, A., Housmans, B. A. C., van der Vloet, L., Surtel, D. A. M., Cremers, A., Marchand, V., Motorin, Y., Caron, M. M. J., Peffers, M. J., & Welting, T. J. M. (2024). TGF-β2 Induces Ribosome Activity, Alters Ribosome Composition and Inhibits IRES-Mediated Translation in Chondrocytes. International Journal of Molecular Sciences, 25(9), Article 5031. https://doi.org/10.3390/ijms25095031
    More information about this publication
  • Ripmeester, E. G. J., Steijns, J. S. J. J., Wijnands, K. A. P., Stassen, R. H. M. J., Pitelka, V., Peeters, L. C. W., Cremers, A., Astryde, N. M. S. A., Chabronova, A., Surtel, D. A. M., Emans, P. J., van den Akker, G. G. H., van Rietbergen, B., van Rhijn, L. W., Caron, M. M. J., & Welting, T. J. M. (2024). The BMP7-Derived Peptide p[63-82] Reduces Cartilage Degeneration in the Rat ACLT-pMMx Model for Posttraumatic Osteoarthritis. Cartilage. Advance online publication. https://doi.org/10.1177/19476035241233659
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  • Steijns, J. S. J. J., Green, D., Peeters, L. C. W., Emans, P. J., Boymans, T. A., Stassen, R. H., van den Akker, G. G. H., Cremers, A., Jutten, L. M. C., Anderson, J. R., Peffers, M. J., Caron, M. M. J., & Welting, T. J. M. (2024). Proteomic characterization of regenerated cartilage following knee joint distraction; a human case-study. Connective Tissue Research, 65(6), 486-496. https://doi.org/10.1080/03008207.2024.2440716
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  • Laagland, L. T., Bach, F. C., Riemers, F. M., Erdmann, G., Braun, T. S., van den Akker, G. G. H., Schmitz, T. C., Creemers, L. B., Sachse, C., Maitre, C. L. L., Welting, T. J. M., Ito, K., Templin, M. F., & Tryfonidou, M. A. (2023). Notochordal Cell-Derived Matrix Inhibits Mapk Signaling In The Degenerative Disc Environment. European Cells & Materials, 46(1), 57-90. https://doi.org/10.22203/eCM.v046a04
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  • Anderson, J. R., Johnson, E., Jenkins, R., Jacobsen, S., Green, D., Walters, M., Bundgaard, L., Hausmans, B. A. C., van den Akker, G., Welting, T. J. M., Chabronova, A., Kharaz, Y. A., Clarke, E. J., James, V., & Peffers, M. J. (2023). Multi-Omic Temporal Landscape of Plasma and Synovial Fluid-Derived Extracellular Vesicles Using an Experimental Model of Equine Osteoarthritis. International Journal of Molecular Sciences, 24(19), Article 14888. https://doi.org/10.3390/ijms241914888
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