PhD Defence Joram Bernd Huckriede
Supervisors: Dr. G.A.F. Nicolaes, Prof. Dr. C.P.M Reutelingsperger
Co-supervisor: Dr. K. Wichapong
Keywords: Histones, COVID-19, Theranostics, Immonothrombosis
"Extracellular Histones as Novel Theranostic Targets in Severe Infection and lmmunothrombosis"
This thesis investigated the effect of a specific type of protein, extracellular histones, in the initiation and progression of severe COVID-19 caused by an infection of the coronavirus. It was found that the presence of extracellular histones could be linked to the risk of development of thrombosis and kidney failure during their stay at the Intensive Care Unit of the hospital. The thesis also investigated the role of several therapeutic options, which include modified activated protein C and neutrophil elastase, that target these extracellular histones. These therapies were successful in reducing the damage and inflammation caused by extracellular histones, and could therefore be an interesting new therapy in the treatment of histone-mediated disease.
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