PhD Conferral Mrs. Maria C.T. (Marcha) Verheijen, MSc.
Supervisor: prof.dr. J.C.S. Kleinjans
Co-supervisor: dr F. Caiment
Keywords: high-throughput techniques, post-transcriptional mechanisms, toxicogenomics research
“Transcriptomics close to my heart: Advanced Models & methods for toxicogenomics research illustrated by anthracycline-induced cardiotoxicity”
Due to immense technological advancements over the last decade, biomedical science has evolved towards more sensitive high-throughput techniques and towards new areas of research, including regulatory mechanisms affecting transcription and translation. The research hypothesizes that the use of an experimental design better reflecting the human in vivo conditions combined with analysis of post-transcriptional mechanisms would aid the evolution of toxicogenomics research in order to improve drug safety assessments in the future. This dissertation describes possible options for realization of this evolution towards improved drug safety assessments.