PhD Conferral Mr. Jarno E.J. Wolters, MSc.
Supervisor: prof.dr. J.C.S. Kleinjans
Keywords: hepatotoxicity, human liver cells, toxic substances
"Toxicogenomics approaches in vitro for unraveling the mechanisms for hepatotoxicity"
People are exposed to harmful substances, i.e. toxins, on a daily basis. As a result, they may develop specific liver diseases which may be associated with morbidity and mortality. However, the underlying mechanisms for the development and progression of these specific liver diseases are largely unknown. By making analyses of genome-wide data over time, this dissertation provides more insight into these mechanisms by exposing healthy human liver cells to various liver toxins. Our results may contribute to the development of better, i.e. more sensitive, biomarkers for diagnosis and development of liver damage.