Dr Ir C.T.A. Evelo
Professional career history
Chris Evelo is head of the Department of Bioinformatics - BiGCaT at
Maastricht University, which he started in 2001. His main research interest is to integrate different bioinformatics approaches to allow real understanding of the data generated in large scale genomics experiments. For this he developes pipelines that start with evaluation of data quality and allow filtering and normalisation (Stan Gaj’s project). Data is then statistically analysed and studied for patterns, gene clusters and profiles. After coupling through genome databases the results can be understood in the context of existing biological knowledge. Since the latter knowledge is domain specific and needs to be formalised we developed a pathway content wiki (see wikipathways.org) and a pathway analysis tool (see pathvisio.org). With these content is developed and used that is specific for research in the nutrition, cardiovascular and toxicology domains. New technology continuously offers new challenges and new chances in genomics. We now concentrate on integration of results along the full gene expression pipeline, from epigenomic imprinting via transcription and translation regulation up to protein modifications (Arie van Erk's and Michiels Adriaens' projects). These analyses are coupled to knowledge integration, for instance for regulatory pathways, which can be derived from literature mining (Andra Waagmeester's project).
Chris intensively collaborates with many research groups from all over the world. He is a member of the council of the European Network of Excellence for Nutritigenomics (NuGO) for which he coordinates the bioinformatics analysis in their proof of principle studies and for the research focus teams.
He is also a member of the council of NUTRIM School for Nutrition, Toxicology and Metabolism.
Professor of Bioinformatics for Integrative Systems Biology