Combine transcriptomics, proteomics and metabolomics studies with epigenomics, ChIP and SNP data and sequence and network analysis;
Systems Biology.
Recent publications
Martens, M., Dierichs, N. T. O. M., Pennings, J. L. A., Piersma, A. H., de Leeuw, V. C., van Oostrom, C. T. M., Malyar, C., Kienhuis, A. S., Evelo, C. T., Willighagen, E. L., & Hessel, E. V. S. (2026). Integrating transcriptomics and molecular AOPs to identify T3-dependent regulation of neuronal development in the human neural progenitor test. Toxicology, 526, Article 154542. https://doi.org/10.1016/j.tox.2026.154542
Houweling, J. M., Arras, M. M. L., Willighagen, E. L., Jennen, D. G. J., Evelo, C. T., & Kienhuis, A. S. (2026). ToxTempAssistant: : using large language models to standardise cell-based toxicological test method descriptions. Evidence-Based Toxicology, 4(1). Advance online publication. https://doi.org/10.1080/2833373X.2026.2638036
Ehrhart, F., Martens, H., Rosenblum, N. D., Schedl, A., Schlesinger, T. A., Gjerstad, A. C., Haffner, D., Ho, J., Evelo, C. T., Woolf, A. S., Weber, R. G., & Schaefer, F. (2026). Molecular pathways of kidney development and their applications to clinical research. Kidney International, 109(2), 287-296. https://doi.org/10.1016/j.kint.2025.09.032
Ozisik, O., Kara, N. S., Abbassi-Daloii, T., Térézol, M., Kuijper, E. C., Queralt-Rosinach, N., Jacobsen, A., Sezerman, O. U., Roos, M., Evelo, C. T., Baudot, A., Ehrhart, F., & Mina, E. (2025). A collaborative network analysis for the interpretation of transcriptomics data in Huntington’s disease. Scientific Reports, 15(1), Article 1412. https://doi.org/10.1038/s41598-025-85580-4
Wijnbergen, D., Johari, M., Ozisik, O., 't Hoen, P. A. C., Ehrhart, F., Baudot, A., Evelo, C. T., Udd, B., Roos, M., & Mina, E. (2025). Multi-omics analysis in inclusion body myositis identifies mir-16 responsible for HLA overexpression. Orphanet Journal of Rare Diseases, 20(1), Article 27. https://doi.org/10.1186/s13023-024-03526-x
Domínguez-Romero, E., Mazurenko, S., Scheringer, M., Martins Dos Santos, V. A. P., Evelo, C. T., Anton, M., Hancock, J. M., Županic, A., & Suarez-Diez, M. (2025). Response to Letter to Editor by A. Derbalah et al: the role of automation in enhancing reproducibility and interoperability of PBPK models. Briefings in bioinformatics, 26(1), Article bbaf060. https://doi.org/10.1093/bib/bbaf060
Fiaz, H., Khan, A. R., Ehrhart, F., Hussain, M., Evelo, C. T. A., Awan, F. R., & Coort, S. L. M. (2025). Investigating the role of Vitamin D and its targeted gene-pathway interactions involved in cardiometabolic health. International Journal of Health Sciences, 19(3), 29-42. https://doi.org/10.25259/OA04_8774
Kienhuis, A., Krul, C., van Engelen, J., Evelo, C. T., Hessel, E., Hoekman, J., Kramer, N., Krop, E., Masereeuw, R., Moors, E., Negro, S. O., Piersma, A. H., Pieters, R., Teunis, M., Willighagen, E., & Legler, J. (2025). The Virtual Human Platform for Safety Assessment (VHP4Safety) project: Next generation chemical safety assessment based on human data. ALTEX, 42(1), 111-120. https://doi.org/10.14573/altex.2407211
Dominguez-Romero, E., Mazurenko, S., Scheringer, M., dos Santos, V. A. P. M., Evelo, C. T., Anton, M., Hancock, J. M., Zupanic, A., & Suarez-Diez, M. (2024). Making PBPK models more reproducible in practice. Briefings in Bioinformatics, 25(6), Article bbae569. https://doi.org/10.1093/bib/bbae569