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… wall), hypopharynx (the bottom part of the throat, extending from the hyoid bone to the cricoid cartilage), and larynx (supraglottis, glottis, and subglottis) (figure 6). 1 16 Chapter 1 Tobacco-associated HNSCCs arise at all subsites, while human papilloma virus- associated HNSCCs arise primarily from the palatine and lingual tonsils of the oropharynx. Figure 6. Anatomical sites of HNSCC development, Nature Reviews Disease Primers (Nat Rev Dis Primers) Reprinted by permission from Springer … 1. The individual E-nose value of each patient are plotted. Values > 0 are scored as being positive for Colon cancer. Values < 0 are scored as being positive for HNSCC. The Red dots are patients with histopathologic confi rmed Colon cancer and the blue dots represent patients with histopathologic confi rmed HNSCC cancer. Figure 2. ROC curve of HNSCC and colon cancer. The ROC-curve illustrates the different sensitivities and specifi cities with altered thresholds of both the best fi t of the data … method has some disadvantages: cost, its time-consuming procedure; and the need for well trained personnel to collect and analyze the samples. Furthermore, the identification of detected compounds is not straightforward; reference libraries have to be checked and validated using the mass and retention time of known standards. 49 E-nose technology for discriminating head and neck, bladder and colon carcinomas Another method, the one used in this study, is e-nose technology, which is based on pattern …

… in the European Union’ (2014) 15(7) German Law Journal, 1223, 1238. 71 Case 98/80 Romano v Institut national d’assurance maladie-invalidité ECLI:EU:C:1981:104 [20]. 72 Merijn Chamon, ‘EU Agencies between Meroni and Romano or the Devil and the Deep Blue Sea’ (2011) 48 Common Market Law Review 1055, 1072. Belgian private law, the decentralised agencies are created under Union law, having their legal bases in the TFEU. In addition, the Court’s “balance of powers” argument appears to refer more to … it refers explicitly to Community law, rather than Union law.120 The Council maintains that the reference to Community law is a conscious choice of the legislator, and subsequently entails that the agency cannot act in the field of the former third pillar, unless it is requested to do so by one of the institutions.121 From a legal point of view, the Council’s argument does not hold up, as the entry into force of the Lisbon Treaty should have led to an automatic substitution of all references to … in the legislative process will be considered. This will be followed by an evaluation of the FRA’s response to two situations with negative fundamental rights implications in the Union. 159 Nadja Milanova, ‘EU Agency for Fundamental Rights: A reality check’ 34 available at http://www.hrwf.net/index.php/publications/reports/115-2011/483-eu-agency-for-fundamental-rights- fra-a-reality-check, last accessed 28 August 2019. 160 Ramboll, ‘2012 External Evaluation of the European Union Agency for …