Search results

… is of importance in the context of public health. However, while glial cells are known to play an important role in brain metabolism overall, their particular metabolic functions and interactions are far from understood. Hypothesis and Objectives: This project will study the metabolic functions of different types of glial cells, as well as their metabolic interactions, and how these are affected in aging and different pathological conditions. Setting and Methods: The project will make use of … diseases and other pathological conditions could help to elucidate disease mechanisms as well as suggest potential intervention strategies – with strong potential impact in healthy aging and disease diagnosis and therapy. Requirements candidate: Highly motivated student with good English communication skills and proactive and resolute attitude. The project requires good programming skills and an interest for the complexity and diversity of the brain’s heterocellular population. The ideal candidate would have a foundation in biochemistry and cellular metabolism on the one hand, and some computational skills on the other hand, preferably in Matlab. Applications with background in only the biochemical or computational side are still …

… Aging involves intertwined processes on cellular and tissue levels. In particular, cellular senescence, a heterogeneous phenotype of permanent growth arrest, is an important driver of aging in tissues. Interventions against aging, e.g. by targeting this senescent state, could extend the healthy lifespan and contribute to regenerative medicine. Cellular senescence has significant ties to metabolism, suggesting potential intervention strategies; however, these ties need to be characterized further. Hypothesis and Objectives: This project will study the metabolic changes accompanying cellular aging and in particular senescence with the goal of identifying possible new signatures and biomarkers, as well as possible metabolic targets for more selective and specific drugs …

… and psychological well-being. 2) Understanding how singlehood affects obesity (risk) and psychological well-being, and vice versa. Setting and Methods: Cross-cultural, mixed methods (qualitative, experimental, survey) research. Impact: At the end of this project, we have a comprehensive overview of the influence of cultural differences and sex ratios on single, ‘surplus’ men, as well as their risk for obesity, self-perceptions, and physical and psychological well-being. Requirements candidate: Highly motivated student with excellent English communication skills and proactive and resolute attitude. Keywords: obesity, evoluationary psychology, mating, cross-culture Top 5 selected publications: 1. Bartholomew-Eldredge, L. K., Markham, C. M., Ruiter, R. A., Kok, G., & Parcel, G. S. (2016). Planning health promotion programs: an intervention mapping approach. John Wiley & Sons. (cited 1874 times). 2. Baams, L., Bos, H., & Jonas, K. J. (2014). How a romantic relationship can protect same-sex attracted youth from the impact of expected rejection. Journal of Adolescence, 37, 1293-1302. (cited 8 times). 3. Ten Hoor, G. A., Kok, G., Peters, G. J. Y., Frissen, T., Schols, A. M., & Plasqui, G. (2017). The psychological …

… (PCI; e.g., HIV, depression) is a challenge for contemporary organizations, worldwide. PCI often experience limited career opportunities and lack of managerial support, despite their equal performance compared to healthy peers. This project seeks to garner new insights about factors promoting and impeding the employability of PCI, that extends earlier research on dimensions of stigma and awareness of the problem among HRM and management. It also establishes the specific … and Objectives: (1) What is the experience of individuals with chronic illness regarding their employability and the support of leaders and HRM? (2) How does disclosure of chronic illness affect employability (e.g., glass-ceiling effect) and how is this impacted by support from leaders? (3) How does moral leadership influence the post-disclosure experience? This list is not exhaustive, the specific focus can be adjusted depending on the interests of the candidate. Setting and Methods: Mixed methods will be employed. Interview studies will be conducted to gain initial insights, and a more general overview will be obtained with large scale longitudinal- …

… Faculty of Humanities and Sciences Project title: Spatial game-theoretical models of cancer treatment Project leader: dr. Kateřina Staňková (www.stankova.net) Function: Assistant professor Collaborators: prof. Frank Thuijsman, prof. dr. ir. Ralf Peeters, dr. Gijs Schoenmakers, prof. Joel S. Brown (Moffitt Cancer Center, Tampa, US) Proposal: The “war on cancer” introduced by Nixon in 1971 shaped the objective of cancer treatments to attempt maximal cancer cell death at all costs. Naturally, the outcome of this language was the implementation of the maximum tolerable dose paradigm. In metastatic castrate resistant prostate cancer, abiraterone is given at a daily maximal dose until treatment failure, adding only 3.9 months of survival versus placebo. This treatment failure is caused by evolution of resistance to abiraterone, similar to evolution of resistance in pests when pest control is introduced. Unfortunately, incorporating techniques that attempt to delay or prevent this evolution of …

… Biobased materials; Maastricht University, The Netherlands). E-mail: sanjay.rastogi@maastrichtuniversity.nl Keywords: High Impact, High Strength, High Modulus, Thermoplastic, Biomedical. Introduction: Polyester materials such as polycaprolactone (PCL) can be biocompatible and biodegradable polymers useful for a wide range of applications, including biomedical and textile applications. These polymers because of their biocompatibility and biodegradability are often used for medical applications such as scaffolds for bone and tissue regeneration. However, the PCL does not exhibit the required mechanical performance required for several demanding applications (tensile modulus ≥ 15 GPa, tensile strength ≥ 2 GPa). Hypothesis and Objectives: In this proposal we aim to improve the mechanical properties of commercial grades of PCLs with strong reinforcing fillers including Ultra-High Molecular Weight PolyEthylene (UHMWPE) and other biodegradable components. In particular, UHMWPE is known to … uniaxially oriented fibers will be achieved using a melt and solution processing lines. The molecular weight and the thermal properties of the used polymers will be characterized using rheometry, Gel Permeation Chromatography (GPC) and differential scanning calorimetry (DSC). Crystalline structure will be studied using small angle and wide angle x-ray diffraction (SAXS and WAXS). Requirements candidate: The candidate having passion to research should have background in physical chemistry and in …

… of Alzheimer’s disease conversion in subjects with MCI •Achieving a high predictive accuracy •Based only on simple, non-invasive predictors which are either already routinely assessed or effectively introducible in clinical practice * Data used in this study were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). The ADNI was launched in 2003 as a public-private partnership, led by Principal Investigator Michael W. Weiner, MD. The primary goal of ADNI has been to test whether serial magnetic resonance imaging (MRI), positron emission tomography (PET), other biological markers, and clinical and neuropsychological assessment can be combined to measure the progression of mild cognitive impairment (MCI) and early Alzheimer’s disease (AD). For up-to-date information, see www.adni-info.org. Features Clinical information Sociodemographic information Neuropsychological tests; …

… the EU and Thailand with a view to promoting multilateralism in international investment and trade. The first day of the Symposium investigated the past experiences of Investor–State Dispute Settlement (ISDS) and the possibility of a global reform of this system. In recent years, the legitimacy of ISDS has come under fire due to high profile cases of investors’ challenges against States’ regulatory actions. Within EU Member States, citizens and NGOs have led calls for greater transparency and … standards and dispute settlement reform within the EU. The new mechanism for resolving investment disputes is known as the Investment Court System (ICS) and it has been included in the EU’s free trade and investment protection agreements with Canada, Singapore, Vietnam, and Mexico. The EU has also been improving substantive standards in its investment agreements in order to safeguard the right of States to regulate. The EU vision of the new model of investment dispute settlement in the form … EU and Thailand. About organising universities Thammasat University is located at the centre of Bangkok, Thailand. It was inaugurated in 1934 and has offered legal education ever since. The origin of the Thammasat University, Faculty of Law (TU Law) can be traced back to the Law School of the Ministry of Justice established in 1897. TU Law is the oldest continuously operating law school in the country and plays a significant role in shaping Thai ideologies, politics, legal education and the …

… Societies, Economies and Enterprises 3rd Annual Conference 2023 Track: Uncertainty in Empirical Macroeconomics Maastricht, the Netherlands, 23-25 October 2023 Track Chairs: Giulia Piccillo, Poramapa Poonpakdee Description of the track The aim of this track is to bring together empirical evidence that helps bridging the gap between theoretical uncertainty and macroeconomic models. Uncertainty has long been linked to adverse macroeconomic outcomes transmitted through various mechanisms such as … expectations. Knight (1921) identified two types of uncertainty: ambiguity and risk, and Ellsberg (1961) theoretically showed that people respond differently to each. Ambiguity refers to a situation in which the probability of a future event cannot be determined, while risk describes events where the likelihood is known. However, it is yet unclear to what extent these two concepts of uncertainty can be applied to the transmission mechanisms in macroeconomic models. Furthermore, there is scarce evidence on how ordinary economic agents, such as households, adjust to aggregate uncertainty or if it aligns with decision-making theories used in …