Sasha Verrijt
Faculty of Health, Medicine & Life Sciences | Bachelor Biomedical Sciences
"Defining the Immunogenicity of Embryonic Stem Cell-derived Dopaminergic Neurons"
Sasha's elevator pitch
Stem-cell based therapies might prove to be long-term solutions to Parkinson’s Disease. This thesis investigated the immunogenicity of human-derived embryonic stem cell (hESC) grafts in a mouse model, as well as the difference in immunogenicity between MHC-knock out ESCs and wildtype ESCs. The current study depicted that the immunogenicity of in vivo matured A9 dopaminergic neurons is constant over three months post-transplantation, that the MHC-KO of hESCs was successful and that they could be matured into ventral midbrain-specific neural progenitor cells. The current research was performed in the lab of Prof. Roger Barker at the University of Cambridge.
Congratulations Sasha
In this video Sasha is addressed briefly by the immediate supervisor.