Research

Bio(mimetic) sensing

Biosensors are characterised by the biological recognition element they use to recognize their target. Over the past few decades, biosensors have evolved from something as simple as a canary in a coalmine to sense toxic gases to technologically advanced devices that continuously monitor e.g. blood glucose levels.

Although biosensor research has led to the development of several commercial enzymatic sensor applications, there are drawbacks associated with the use of natural receptors. Their limited stability in challenging environments (temperature, pH) makes it complex to integrate them into disposable sensor strips. Synthetic receptors that have a similar affinity for their target but are superior in thermal, mechanical, long-term and chemical stability can offer solutions.

Therefore, the Sensor Engineering department has devoted a lot of research to the development of so-called molecularly imprinted polymers (MIPs) that can replace the antibodies or enzyme traditionally used in biosensors to create cheaper, more robust biomimetic sensors. MIPs have shown to be particularly suited for the detection of small molecules in aqueous solutions. The detection of larger entities, ranging from proteins to microorganisms or whole cells can be done in a similar way. Flat polymer layers are imprinted with the target and removed, creating a pattern of micron-sized molds on the surface of these so-called surface-imprinted polymers (SIPs).