NUTRIM Division II

NUTRIM Division 2

Liver & Digestive Health

Aim of NUTRIM's Division 2

Research performed in this division encompasses human intervention studies, epidemiological and fundamental in vivo and in vitro research.

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Research Themes

The availability of patient cohorts combined with research expertise in metabolism, immunity, epidemiology, surgery and microbiology allows us to integrate different perspectives on complex interactions between genetics and environment leading to pathologies.

Research Focus

NUTRIM Division 2, aims to provide novel insight into the pathophysiological processes of the gut and liver and translate these findings to the clinic. The division researches various disorders including inflammatory bowel disease, liver failure, irritable bowel syndrome, cancer cachexia, cholestasis and non-alcoholic steatohepatitis.

The main research focus lies within liver and digestive health and particularly on the complex interaction between host genetics, diet, lifestyle and the microbiome. Division II also aims to extrapolate research findings to related organ systems such as the cardiovascular or central nervous system. In addition, it examines inter-organ crosstalk (e.g. gut-brain axis) as well as the role of microbiome on host physiology and different pathologies.

Research Impact

The close collaboration between epidemiologists, geneticists, basic scientists and clinicians as well as the proximity of the MUMC and Maastricht University strongly serve this division’s goal to perform translational research aiming to improve the diagnosis and therapy of the patient in the clinic. Our division generates novel approaches for the diagnosis (biomarkers) and treatment of gut-liver disorders.

Collaborating departments, research performed in both basic and clinical departments*.

Collaborating departments in Division 2


  • Favourable gut flora in very young infants reduces their chances of developing allergies. Good gut bacteria that leave anti-inflammatory metabolites in the intestinal tract are much more prolific in non-allergic children. This was the finding of a long-term study by Maastricht researchers on the gut...