On-Site PhD conferral mr. Tim Klaassen
Supervisor: Prof.dr. A.A.M. Masclee
Co-supervisors: Dr. D. Keszthelyi, Dr. F.J. Troost
Key words: satiety, obesity, anorexia, functional dyspepsia, tastants, lidocaine, questionnaires
"Novel strategies to address disrupted sensing and signalling of satiety"
Various clinical situations can influence energy intake and sensing and signalling of satiety. Increased energy intake and diminished satiety signalling can be seen in the case of overweight and obesity. On the other hand, decreased energy intake and increased satiety can be seen in the ageing population, also known as anorexia of ageing. Furthermore, abnormal sensations such as recurring pain, stress, and anxiety can influence energy intake and satiety signalling. This in turn can result in food intake disorders such as avoidant/restrictive food intake disorder. Administering tastants, especially bitter tastants, in the gastrointestinal tract can result in decreased energy intake. Intragastric administration of lidocaine did not result in increased energy intake. A novel tool was developed in order to provide more insight in the disrupted sensing and signalling of satiety seen in the disorder functional dyspepsia.
