Predicting risk of thrombosis and bleeding
This edition of the Forum is focused on applications of Systems Biology methods to predicting risk of thrombosis and bleeding. Thrombosis, or the formation of a thrombus, relies on the interactions of blood platelets and the coagulation system with the damaged vessel wall.
To mimic these processes, a multiparameter assay has been developed in the Biochemistry department of UM, in which small volumes of blood are perfused over an array of components of the vessel wall, and where both platelet activation and coagulation can be observed in time. By using multicolour microscopy, over hundred parameters can be obtained for a given blood sample. To evaluate the interactions and relevance of these parameters, several mathematical modelling approaches are being developed and applied.
This working group brings together researchers in the Maastricht area who are interested in the development and application of “systems biology”. The main aim is to share research, experience and, through this exchange, inspire and initiate new research directions and collaborations. The meeting takes place roughly every three months in the Brains Unlimited building.
One hundred ways to measure a thrombosis or bleeding tendency in whole blood with clever ways of mathematical modeling
Johanna van Geffen (CARIM)
Johan Heemskerk (CARIM)
Rachel Cavill (DKE)
In the interactive presentation, we will first provide some clinical background on venous and arterial thrombosis (heart attack, stroke). We will sketch our current understanding about the roles of platelets and coagulation in these pathologies. We will then explain how so many parameters can be obtained using small volumes of blood.
|18:30||Networking over drinks/snacks|
Drinks and snacks provided
The working group also encourages researchers to make an "Ideas/challenges pitch". A pitch is a short (approx. 5 min) presentation showcasing an interesting idea, tool, or challenge that invites others to collaborate. Pitches can include both computational approaches and physiological / clinical questions where a systems biology approach could be helpful.
If you would like to give a pitch at a subsequent meeting, please fill out the form below to contact John Walmsly.