28 Jun

PhD conferral Yawen Wang

Supervisor: Prof. Dr. Peter De Weerd

Co-supervisors: Dr. Mark J. Roberts, Dr. Sriranga Kashyap (University Health Network)

Keywords: nucleus basalis of Meynert, brightness perception, ultra-high field (f)MRI

"Challenges and Potential of 7T (f)MRI for Investigating Attention and Perception

Attention and perception are fundamental components of the brain that have been extensively studied over the years. This thesis aims to advance our understanding how the brain processes attention and perception using advanced imaging techniques like functional magnetic resonance imaging (fMRI) at ultra-high field (UHF).

The cholinergic system plays a vital role in attentional control, making the nucleus basalis of Meynert (nbM) an initial focus of the research as it serves as the primary source of cortical acetylcholine. Previous MRI studies that attempted to locate the nbM are critically reflected, by analyzing their methods, limitations, and potential areas for improvement. To explore the neural mechanisms involved in visual perception, the research employs a classic brightness induction paradigm during 7T fMRI scans. Additionally, the development of experimental brightness illusion stimuli is involved, which might prove valuable for future studies using neuroimaging techniques.

By delving into these areas, this thesis aims to contribute valuable insights to answer these open questions in modern neuroscience.

Language: English

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