PhD Conferral Mrs. Heleen Zandstra, MSc.
Supervisor: prof.dr. J.H.L. Evers
Co-supervisors: dr. A.P.A. van Montfoort, dr. J.C.M. Dumoulin
Keywords: IVF, ICSI, fertility, culture medium, follow-up
“IVF culture medium and long-term child development”
In an IVF treatment, embryos are grown for 2-3 days in a culture fluid. Previous studies have shown that a short stay in this fluid has an effect on the birthweight of the child born 9 months later. In this thesis, it was exammined whether the culture fluid has a long-term effect on the development of IVF-children. This indeed turned out to be the case: at the age of nine, children who spent several days in one medium as an embryo weighed one and a half kilos heavier than in another medium. Small embryonic changes may therefore potentially affect health in later life.
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