PhD conferral mrs. Anne B. Koopmans
Supervisors: prof.dr. P.N. van Harten, prof.dr. H.W. Hoek, RUG
Co-supervisor: dr. D.J. Vinkers
Keywords: CYP2D6, CYP2C19, pharmacogenetics, genotyping, clinical practice
"CYP2D6 and CYP2C19 genotyping in psychiatry - Bridging the gap between practice and lab"
CYP2D6 and CYP2C19 are liver enzymes that play an important role in the breakdown of psychopharmaceuticals. The number of active alleles in the DNA determines how quickly these enzymes work and is translated into a phenotype. This phenotype can vary greatly per person and per ethnicity. There is a relationship between the speed of the enzyme and the occurrence of medication side effects. This study has mapped the prevalence of the different phenotypes worldwide. It has also been investigated whether there are fewer side effects in patients taking antipsychotics if you adjust the dosage of medication to the phenotype.