PhD conferral dhr. Emanuel E. Canfora, MSc
Supervisor: Prof.dr. E.E. Blaak
Co-supervisor: Dr. J.W. Jocken, Dr. K. Lenaerts
Keywords: Obesity, Gut microbiota, dietary fibers, short-chain fatty acids, human metabolism
Title: “Short-Chain Fatty Acids; the link between gut microbiota and metabolic health”
Minderbroedersberg 4-6
Global obesity rates are increasing more and more. Short-chain fatty acids, the end products of fermentation of indigestible carbohydrates by intestinal bacteria, can influence metabolism and therefore play a role in the development of obesity and diabetes. The studies described in this dissertation show that the administration of short-chain fatty acids to the colon of overweight men increases energy expenditure and fat metabolism and reduces appetite and inflammation. The increase in the number of short-chain fatty acids in the colon by food intake can vitally contribute to the treatment or prevention of obesity and diabetes.
Funder: TI Food and Nutrition (GH003).
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