Modelling brain energy metabolism
The brain consumes an inordinate amount of energy with respect to its weight. Understanding brain energy metabolism is crucial as numerous studies point to a metabolic component in various neurodegenerative disorders and because energetic considerations might have played an important role during evolution, constraining behavior and providing a powerful explanation of certain cellular features as trade-offs between performance in information processing and energy savings.
Prof. Jolivet from the Department of Nuclear and Particle Physics, University of Geneva will briefly discuss these points before describing how to design models of brain energy metabolism, the importance of calibration due to the multicellular complexity of the brain and algorithmic tools to analyze the behavior of such models. Prof. Jolivet will also speculate on how the approach discussed can be extended to other organs.
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