The study of persons in the context of normal daily life may provide a powerful and necessary addition to more conventional and cross-sectional research strategies in psychopathology. The Experience Sampling Method (ESM), also known as Ecological Momentary Assessments (EMA), is a mobile assessment approach designed to measure thoughts, mood, symptoms, and contextual information in the flow of daily life. ESM thus allows to capture the film rather than a snapshot of daily life reality of patients or research subjects. ESM has been proven to be feasible in patients with a wide range of psychopathology, including schizophrenia, major depression, bipolar disorder, eating disorder, and personality disorders. The availability of mobile technology as the PsyMate™ allows easy implementation of ESM in your practice.