Tim Vanmierlo (T.)
Schepers, M., Paes, D., Tiane, A., Rombaut, B., Piccart, E., van Veggel, L., Gervois, P., Wolfs, E., Lambrichts, I., Brullo, C., Bruno, O., Fedele, E., Ricciarelli, R., Ffrench-Constant, C., Bechler, M. E., van Schaik, P., Baron, W., Lefevere, E., Wasner, K., ... Vanmierlo, T. (2023). Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis. Brain Behavior and Immunity, 109(1), 1-22. https://doi.org/10.1016/j.bbi.2022.12.020
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Tiane, A., Schepers, M., Reijnders, R. A., van Veggel, L., Chenine, S., Rombaut, B., Dempster, E., Verfaillie, C., Wasner, K., Gruenewald, A., Prickaerts, J., Pishva, E., Hellings, N., van den Hove, D., & Vanmierlo, T. (2023). From methylation to myelination: epigenomic and transcriptomic profiling of chronic inactive demyelinated multiple sclerosis lesions. Acta Neuropathologica, 146(2), 283-299. https://doi.org/10.1007/s00401-023-02596-8
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Paes, D., Schepers, M., Willems, E., Rombaut, B., Tiane, A., Solomina, Y., Tibbo, A., Blair, C., Kyurkchieva, E., Baillie, G. S., Ricciarelli, R., Brullo, C., Fedele, E., Bruno, O., van den Hove, D., Vanmierlo, T., & Prickaerts, J. (2023). Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology. Cellular and Molecular Life Sciences, 80(7), Article 178. https://doi.org/10.1007/s00018-023-04804-w
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Schepers, M., Malheiro, A., Gamardo, A. S., Hellings, N., Prickaerts, J., Moroni, L., Vanmierlo, T., & Wieringa, P. (2023). Phosphodiesterase (PDE) 4 inhibition boosts Schwann cell myelination in a 3D regeneration model. European Journal of Pharmaceutical Sciences, 185(1), Article 106441. https://doi.org/10.1016/j.ejps.2023.106441
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Mussen, F., Broeckhoven, J. V., Hellings, N., Schepers, M., & Vanmierlo, T. (2023). Unleashing Spinal Cord Repair: The Role of cAMP-Specific PDE Inhibition in Attenuating Neuroinflammation and Boosting Regeneration after Traumatic Spinal Cord Injury. International Journal of Molecular Sciences, 24(9), Article 8135. https://doi.org/10.3390/ijms24098135
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Koulousakis, P., Tiane, A., Hellings, N., Prickaerts, J., van den Hove, D., & Vanmierlo, T. (2023). A perspective on causality assessment in epigenetic research on neurodegenerative disorders. Neural Regeneration Research, 18(2), 331-332. https://doi.org/10.4103/1673-5374.343898
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https://orcid.org/0000-0003-2912-0578
https://pubmed.ncbi.nlm.nih.gov/?term=vanmierlo+t
Tim Vanmierlo (T.)
Tim Vanmierlo holds a position as an associate professor between Maastricht University (0.5fte) and Hasselt University (0.5fte) and on the research line "repair-inducing cognition enhancers". In this context, his team applies a battery of gene-editing approaches (e.g. CRISPR/Cas9, in vivo micro-electroporation) to modulate biological processes to enable CNS repair in MS and AD. The established cross-border initiative between UHasselt BIOMED with the school for mental health and neuroscience (MHeNs) at Maastricht University merges knowledge and expertise on cognition enhancers applying gene-editing approaches.
Fundamentele Neurowetenschappen 2
Psychiatrie & Neuropsychologie
School for Mental Health and Neuroscience
Fac. Health, Medicine and Life Sciences