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Tim Vanmierlo (T.)

Key publicaties
  • Schepers, M., Paes, D., Tiane, A., Rombaut, B., Piccart, E., van Veggel, L., Gervois, P., Wolfs, E., Lambrichts, I., Brullo, C., Bruno, O., Fedele, E., Ricciarelli, R., Ffrench-Constant, C., Bechler, M. E., van Schaik, P., Baron, W., Lefevere, E., Wasner, K., ... Vanmierlo, T. (2023). Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis. Brain Behavior and Immunity, 109(1), 1-22. https://doi.org/10.1016/j.bbi.2022.12.020
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  • Tiane, A., Schepers, M., Reijnders, R. A., van Veggel, L., Chenine, S., Rombaut, B., Dempster, E., Verfaillie, C., Wasner, K., Gruenewald, A., Prickaerts, J., Pishva, E., Hellings, N., van den Hove, D., & Vanmierlo, T. (2023). From methylation to myelination: epigenomic and transcriptomic profiling of chronic inactive demyelinated multiple sclerosis lesions. Acta Neuropathologica, 146(2), 283-299. https://doi.org/10.1007/s00401-023-02596-8
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  • Paes, D., Schepers, M., Willems, E., Rombaut, B., Tiane, A., Solomina, Y., Tibbo, A., Blair, C., Kyurkchieva, E., Baillie, G. S., Ricciarelli, R., Brullo, C., Fedele, E., Bruno, O., van den Hove, D., Vanmierlo, T., & Prickaerts, J. (2023). Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology. Cellular and Molecular Life Sciences, 80(7), Article 178. https://doi.org/10.1007/s00018-023-04804-w
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  • Schepers, M., Malheiro, A., Gamardo, A. S., Hellings, N., Prickaerts, J., Moroni, L., Vanmierlo, T., & Wieringa, P. (2023). Phosphodiesterase (PDE) 4 inhibition boosts Schwann cell myelination in a 3D regeneration model. European Journal of Pharmaceutical Sciences, 185(1), Article 106441. https://doi.org/10.1016/j.ejps.2023.106441
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  • Mussen, F., Broeckhoven, J. V., Hellings, N., Schepers, M., & Vanmierlo, T. (2023). Unleashing Spinal Cord Repair: The Role of cAMP-Specific PDE Inhibition in Attenuating Neuroinflammation and Boosting Regeneration after Traumatic Spinal Cord Injury. International Journal of Molecular Sciences, 24(9), Article 8135. https://doi.org/10.3390/ijms24098135
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  • Koulousakis, P., Tiane, A., Hellings, N., Prickaerts, J., van den Hove, D., & Vanmierlo, T. (2023). A perspective on causality assessment in epigenetic research on neurodegenerative disorders. Neural Regeneration Research, 18(2), 331-332. https://doi.org/10.4103/1673-5374.343898
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Recente publicaties
  • van Veggel, L., Schepers, M., Tiane, A., Kumar, V., Willems, E., Rombaut, B., Noordijk, J., Vangansewinkel, T., Li, A., Wolfs, E., Ozcan, B., Nouboers, E., Moya, P. R., Sauer, D. B., Diliën, H., Hellings, N., Schreiber, R., & Vanmierlo, T. (2025). EAAT3 modulation: A potential novel avenue towards remyelination in multiple sclerosis. Biomedicine & Pharmacotherapy, 186, 117960. Article 117960. https://doi.org/10.1016/j.biopha.2025.117960
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  • Martens, N., Zhan, N., Yam, S. C., Palumbo, M., Pontini, L., Leijten, F. P. J., van Vark-van Der Zee, L., Voortman, G., Friedrichs, S., Gerding, A., Marinozzi, M., Jonker, J. W., Kuipers, F., Luetjohann, D., Vanmierlo, T., & Mulder, M. T. (2025). Role for the liver X receptor agonist 22-ketositosterol in preventing disease progression in an Alzheimer's disease mouse model. British Journal of Pharmacology, Article 70031. Advance online publication. https://doi.org/10.1111/bph.70031
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  • Schepers, M., Vangansewinkel, T., Libberecht, K., Jeurissen, H., Jacobs, D., Piccart, E., Prior, R., Ricciarelli, R., Brullo, C., Fedele, E., Bruno, O., Prickaerts, J., Lambrichts, I., Van Den Bosch, L., Vanmierlo, T., & Wolfs, E. (2025). Phosphodiesterase 4D inhibition improves the functional and molecular outcome in a mouse and human model of Charcot Marie Tooth disease 1 A. Biomedicine & Pharmacotherapy, 183, Article 117828. https://doi.org/10.1016/j.biopha.2025.117828
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  • Van Broeckhoven, J., Mussen, F., Schepers, M., Vanmierlo, T., & Hellings, N. (2025). A new player in the game: identification of C1ql1 as a novel factor driving OPC differentiation. FEBS Journal, 292(1), 47-51. https://doi.org/10.1111/febs.17321
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  • Schuetz, L. T., Duran, G., Baeten, P., Lintsen, D., Hermans, D., Chenine, S., Verreycken, J., Vanmierlo, T., Wouters, K., & Broux, B. (2024). Sex differentially affects pro-inflammatory cell subsets in adipose tissue depots in a diet induced obesity model. Biology of Sex Differences, 15(1), Article 105. https://doi.org/10.1186/s13293-024-00677-1
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  • Vanbrabant, K., Rasking, L., Vangeneugden, M., Bove, H., Ameloot, M., Vanmierlo, T., Schins, R. P. F., Cassee, F. R., & Plusquin, M. (2024). Impact on murine neurodevelopment of early-life exposure to airborne ultrafine carbon nanoparticles. Particle and Fibre Toxicology, 21(1), Article 51. https://doi.org/10.1186/s12989-024-00612-7
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  • Donders, Z., Skorupska, I. J., Willems, E., Mussen, F., Broeckhoven, J. V., Carlier, A., Schepers, M., & Vanmierlo, T. (2024). Beyond PDE4 inhibition: A comprehensive review on downstream cAMP signaling in the central nervous system. Biomedicine & Pharmacotherapy, 177, Article 117009. https://doi.org/10.1016/j.biopha.2024.117009
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  • Leenders, F., Koole, L., Slaets, H., Tiane, A., Hove, D. V. D., & Vanmierlo, T. (2024). Navigating oligodendrocyte precursor cell aging in brain health. Mechanisms of Ageing and Development, 220, Article 111959. https://doi.org/10.1016/j.mad.2024.111959
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  • Schepers, M., Hendrix, S., Mussen, F., van Breedam, E., Ponsaerts, P., Lemmens, S., Hellings, N., Ricciarelli, R., Fedele, E., Bruno, O., Brullo, C., Prickaerts, J., Van Broeckhoven, J., & Vanmierlo, T. (2024). Amelioration of functional and histopathological consequences after spinal cord injury through phosphodiesterase 4D (PDE4D) inhibition. Neurotherapeutics, 21(4), Article e00372. https://doi.org/10.1016/j.neurot.2024.e00372
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  • Sin, Y. Y., Cameron, R. T., Schepers, M., MacLeod, R., Wright, T. A., Paes, D., van den Hove, D., Willems, E., Vanmierlo, T., Prickaerts, J., Blair, C. M., & Baillie, G. S. (2024). Beta-amyloid interacts with and activates the long-form phosphodiesterase PDE4D5 in neuronal cells to reduce cAMP availability. Febs Letters, 598(13), 1591-1604. https://doi.org/10.1002/1873-3468.14902
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Overige publicaties

https://orcid.org/0000-0003-2912-0578

https://pubmed.ncbi.nlm.nih.gov/?term=vanmierlo+t