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… Drug to Market Discovery Research – preclinical, in test tubes then animals Brain Target Clinical Research & Development In humans; healthy volunteers then patients Courses aligned to drug research & development pipeline Core Courses Practicals Workshops Parallel Courses This is about finding new medicinal drugs and making them work for dementia, depression, schizophrenia, autism, ADHD, . . . . . . ., basically all neuropsychiatric diseases that can be targeted biologically Discovery ~7yrs Development ~8yrs Registration Drug to Market Discovery Research – preclinical, in test tubes then animals Brain Target Clinical Research & Development In humans; healthy volunteers then patients Courses … 3 Maastricht; 1 Amsterdam) Excursions to companies in the first year: • UCB (Brussels, Belgium) • Johnson & Johnson (Beerse, B) • Bayer (Wuppertal, Germany) • Grünenthal (Aachen, Germany) RMa Cognitive and Clinical Neuroscience Who can apply Students with a BA in: - Neuroscience - Psychology - Biomedical Science - Pharmacy - Medicine - Life Sciences - Bioengeneering - University College - Science College - … For more information • Talk with student and coordinator after the presentation • Contact …

… Holidays: April 27 May 4, 5, 14, 15 and 25 • Mind that courses may have pre-requisites, e.g. the course Comparative Legal History of the Limbourgish Territories (MET3006) requires advanced (passive) knowledge of French and/or German and/or Dutch. You can find prerequisites in the course description on the website. • See also the information for incoming exchange students about the pre-requisites of courses in the bachelor European Law School. • We advise students to choose two courses of 6 credits each or one course of 11 credits per period, with the exception of the third period where it’s advisable to choose just one course. Mind, if you take an extra course, you will have to deal with a study load that is above average! • Bachelor's students can only take courses from the Bachelor's programme. No rights may be derived from this memorandum. We reserve the right to make changes. …

… and optimize human movement in relation to health and disease, aging and (sports) performance What is HMS about? American Heart Association's Scientific Sessions November 2018 What is HMS about? What is HMS about? Elderly fall more frequently! Do they stumble more often or are they less able to control incident stumbles? Would resistance training be beneficial? Fall risk in elderly A Prehabilitation • Optimize the patient’s physical fitness prior to surgery • Nutritional state • Psychological state Time between contemplation of surgery and the procedure Treatable moment Improving postoperative outcomes A sedentary lifestyle has been associated with various chronic diseases! Is exercise necessary? Can daily non-exercise activity do the job? How can we assess daily activity? What is the dose-response relation? Sitting time is an important health risk From BBC.com Everyone loves a fairytale, … First year: Friday courses • Second year: Tuesday courses • All combined with full-time students • In principle, all teaching on one day • Part-time = half time (20 hours/wk) Part-time programme • Problem-based learning • Interactive lectures and workshops • Practicals in small groups • Project work • Hands-on experience (real-life setting) • Academic skills training Teaching methods Fact or fashion? Fact or fashion? To apply evidence-based practice in your professional setting • Searching …

… Measuring cells (size) based on electrical condutivity : Coulter 1953 Development of laminair flows: Crosland – Taylor 1965 Electrostatic charges breaks-up a stream in droplets (inktjet printing): Sweet 1967 IBM developed a rapid cell spectrometer with arc lamp and a computer: Kamentsky 1972 Fluorescence Activated Cell Sorter: Herzenberg 1981 First benchtop analyzer 1985 3 colors available Some history Some history Len Herzenberg Some history What’s now? - Flow : cells in motion - Cyto: cell - … Tube Optics Filtersets in front of detectors Optics Filtersets in front of detectors 780/60 BP filter Transmission of photons in the range of 750 to 810 nm Center 780 nm -30 nm +30 nm Optics Detectors Optics Detectors Optics Which fluorchromes can we detect at MUMC+? -> depends on configuration of the machine: BD FACS Canto - 3 laser - 8 colours BD Fusion sorter - 4 lasers - 16 colours Cytek Aurora: full spectrum flowcytometry Optics UV laser (355): 7 channels Violet laser (405): 18 channels … is compensation based on the mean of the negative population 3. The control must match the experimental fluorochrome. This means the tube must be acquired at the same voltage and the exact same fluorochrome has been used  So FITC is compensated with FITC and not Alexa488. Tandem-dyes need lot specific compensation. Optics compensation Optics Fluorchromes  Fluorescent proteins  Green fluorescent protein (GFP), YFP, RFP  PE, APC, PerCpD  Synthetic small molecules  FITC / Cy5  Polymer dyes …

… Project title: How to measure choice behaviour? A comparative study of choice designs with applications in health economics Project leader: Dr. Roselinde Kessels, Assistant Professor of Statistics r.kessels@maastrichtuniversity.nl https://www.maastrichtuniversity.nl/p70066980 https://www.researchgate.net/profile/Roselinde-Kessels … from each other. In the event of simple decision tasks, random utility theory is a good approximation of the decision process. Here is an example of a partial profile task of 4 hypothetical medications where respondents have to choose the profile they prefer given that only 3 out of 5 attributes, indicated in yellow, are varying between the profiles. The other 2 attributes have overlapping levels: Profile 1 Profile 2 Profile 3 Profile 4 Gel Cream Oil Lotion / solution Storage in refrigerator … once opened Fresh for 9 months once opened Using roller ball Using fingers Using pad Using tube Once daily regimen Once daily regimen Once daily regimen Once daily regimen О О О О In contrast to considering all profiles in a choice task, respondents can also use non- compensatory heuristics by screening a choice set and ignoring certain profiles based on their attribute levels. Current research has shown that proper designs for non- compensatory choice models such as screening-rule based choice …

… of the two. However, whereas an altruist orientation tend to dominate in the family, wel- fare state attitudes are more likely guided by some degree of generational self-interest. Methods: This paper explores how attitudes to the welfare state vary with age, and to what extent these attitudes are modified by self-perceived age and ageing. Data from a large-scale Norwegian study, LOGG (n=9 600, aged 18-79), are used to address the questions empirically. Comparative data are drawn from the UN-based … is associated with longer hospital stays, unplanned hospital readmissions, dependence on formal/informal care, and mortality. One of the major reasons is prolonged periods of bedrest and limited physical activity. The kind of care provided by nurses can influence the type and amount of physical activity hospital- ized older adults perform. Therefore researchers in Canada, the Netherlands and the US have initiated care approaches to integrate Function Focused Care (FFC) into acute care. FFC aims to … on preventing functional decline and restoring the optimal func- tional and physical status. A promising approach is function focused care (FFC) developed by Resnick e.a. To enhance effectiveness, interventions have to be adapted systematically before they can be implemented among another target group in another context.This presentation describes the system- atic development of an FFC-based approach for the hospi- tal setting. In an iterative process with experts in FFC and nurses working in …

… 2023 International Client Consultation Competition Environmental Law Problem 1 (Preliminary Round) CONSULTATION FOR LAWYERS MEMORANDUM TO FILE To: Lawyers Date: 13 April 2023 From: Secretary Re: Max Well Max Well has made an appointment to speak with you about whether s/he can get in trouble for a recent protest. (Applicable Law: Each team of student lawyers is entitled to choose the jurisdiction in which this interview is taking place. The student lawyers will normally choose their home country. The client, lawyers, and … about the jurisdiction.) 2023 International Client Consultation Competition Environmental Law Semifinal Round CONSULTATION FOR LAWYERS MEMORANDUM TO FILE To: Lawyers Date: 15 April 2023 From: Secretary Re: Taylor/Tyler Makin You have an appointment with Taylor/Tyler Makin, who seems concerned about a pending sale of property. (Applicable Law: Each team of student lawyers is entitled to choose the jurisdiction in which this interview is taking place. The student lawyers will normally choose their …

… Elective 1 Elective 2 Program and policy evaluation in EM Trade, FDI and global value chains Governance and institutions in EM Supply chain strategy Sustainable and responsible investments Business innovation & sustainable development • MIGRATION African-German labor mobility schemes • TRADE Thailand’s Global value Chain’s participation • SUSTAINABILITY Sino-European Circular Economy Policy projects – examples Professional Development Language courses in: • Spanish • French • Chinese • Russian • Portuguese • Arabic - Thesis Internship Programme (TIP) – 3 to 6 months - Part-time or full-time - Locally or abroad - Write the thesis in collaboration with a firm/organisation - Extra-curricular internship – 2 to 6.5 months How to find them? You’ll have to put in a lot of work, but we can help you: -Vacancies at UM: www.umvacancyboard.nl -Internship office: several years experience with EM internships Internship possibilities Combine your thesis and internship – launch your career Examples of Internships in Latin America Country Institution Mexico Volkswagen Financial Services Mexico Dominican Republic Virtu Rocks Colombia Henkel …

… adviseren over de OER’en. De OC Health stelt zich op het standpunt dat de Nominale Plannen een onderdeel van de OER’en zijn en daarmee vallen onder het instemmingsrecht van de OC Health. 4.4 Actiepunten OC voor 2022-2023 Actiepunten: • Verkenning van online onderwijsmethoden als onderdeel van de onderwijsorganisatie. • Monitoren van werkdruk gerelateerd aan onderzoek en onderwijs, inclusief systematische reflectie met gebruikmaking van relevante indicatoren. • Bespreken van ILOs, waaronder … Application Committee new EPC wp-members (AY 2023-2024) EERs Bachelor GW + BEPH 2023-2024 (discussion + consent) Nominal plan Msc HDT 10 May geannuleerd 09.00-12.00 DEB1-A0.011A 31 May 09.00-12.00 DEB1-A0.011A Individual evaluation meetings with wp-members> scheduling in June Draft meeting schedule EPC HS AY 2023-2024 Nominal Plan MSc Epidemiology 2023-2024 20 June EPC dinner for departing and new EPC members 21 June 09.00-12.00 DEB1-A0.011A Invite new EPC (student/wp) members AY …