florea_-_dissertation.pdf
(2.35 MB, PDF)
… at Maastricht University and Doctor rerum medicinalium (Dr. rer. medic.) at the RWTH Aachen University on the authority of the Rector Magnifici Prof. dr. Pamela Habibović and Univ.-Prof. Dr. rer. nat. Dr. h. c mult. Ulrich Rüdiger, in accordance with the decision of the Board of Deans to be defended in public on Wednesday 8th, March 2023, at 16:00 hours By Alexandru Florea Approved after corrections Prof. dr. Pamela Habibović Rector Magnificus Sodium [18F]Fluoride positron emission tomography … of atherosclerotic plaque formation has evolved tremendously since Ross stated it is an inflammatory disease. Nowadays, atherosclerosis is considered to be a 6-stage disease (Gargiulo et al., 2016), with lesions that occur at predicted sites, where blood flow is turbulent (Figure 2): 1. Local accumulation and oxidation of lipids with slight thickening of the intima. The most notably lipids, which participated in this stage, can be found in LDL and VLDL. 2. Local infiltration of inflammatory … we describe a novel mouse model, which spontaneously develops spotty calcifications, detected by small animal CT, exclusively in the proximal aorta, with no apparent life-span reduction. – 84 – Supplementary Materials: The following are available online at www.mdpi.com/xxx/s1: Figure S1: Ulcerative dermatitis. Author Contributions: conceptualization, A.F., J.B., L.J.S., and F.M.M.; data curation, A.F. and O.H.W.; formal analysis, A.F. and J.P.S.; funding acquisition, J.B., L.J.S., and F.M.M.; …