Estrogen metabolism: its inhibition in hyperplasia and endometrial cancer

The local interconversions between estrone (low activity) and 17β-estradiol (potent compound) by 17β-hydroxysteroid dehydrogenases (17β-HSDs) can lead to high 17β-estradiol generation in endometrial cancer (EC) and therefore cancer growth. In This study we examine the balance between the 17β-HSDs reducing estrone to 17β-estradiol and those oxidizing 17β-estradiol to estrone in EC and in premalignant hyperplasia lesions. 

This research line is coordinated within the Maastricht Endometrium Research Group