Panos Barlampas

  Faculty of Science and Engineering | Bachelor University College Venlo

"Comprehensive review on the efficacy and gut modulation properties of diarrhea-predominant irritable bowel syndrome treatments"

Panos' elevator pitch
Irritable bowel syndrome (IBS) is the most prevalent gastrointestinal condition, and diarrhea-predominant IBS (IBS-D) is the second most predominant subtype, with the lowest perceived quality of life. Although its pathology is not fully elucidated, gut microbiota (GM) has been implicated as a contributing factor. This thesis (a) suggested a potential ranking system for IBS-D interventions, using IBS Symptom Severity Score as the point of comparison, and (b) investigated potential intervention-GM interactions. After comprehensive research, low fermentable oligo-di-monosaccharides and polyol (FODMAP) diets and certain multistrain probiotics emerged as prominent interventions in mitigating IBS-D symptom severity. Definitive characterization of the compositional and functional effect of such interventions in GM pends on additional research.