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Dr F.J. Troost

Research profile

▪  Scientific work, general interest: food innovation, health and nutrition.

▪  Expertise; gastrointestinal processing and health effects of functional dietary ingredients, effects of pre- and probiotics on host metabolism and health, modulation of gut microbiota, sports nutrition,(mucosal) regulation of appetite and satiety, modulation of visceral perception in health and (gastrointestinal) disease, and in general, effects of food and nutrition on health and metabolism.

Intervention models include the use of intestinal feeding/aspiration catheters in any location in the gastrointestinal tract, biological specimen sampling (tissue, secretions, blood), non-invasive dietary interventions, development of biosensors to measure relevant health parameters in humans.

Key publications
  • de Vos, P., Mujagic, Z., de Haan, B. J., Siezen, R. J., Bron, P. A., Meijerink, M., Wells, J. M., Masclee, A. A. M., Boekschoten, M. V., Faas, M. M., & Troost, F. J. (2017). Lactobacillus plantarum Strains Can Enhance Human Mucosal and Systemic Immunity and Prevent Non-steroidal Anti-inflammatory Drug Induced Reduction in T Regulatory Cells. Frontiers in Immunology, 8(AUG), Article 1000. https://doi.org/10.3389/fimmu.2017.01000
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  • Corstens, M. N., Berton-Carabin, C. C., Elichiry-Ortiz, P. T., Hol, K., Troost, F. J., Masclee, A. A. M., & Schroen, K. (2017). Emulsion-alginate beads designed to control in vitro intestinal lipolysis: Towards appetite control. Journal of Functional Foods, 34, 319-328. https://doi.org/10.1016/j.jff.2017.05.003
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  • van Avesaat, M., Ripken, D., Hendriks, H. F. J., Masclee, A. A. M., & Troost, F. J. (2017). Small intestinal protein infusion in humans: evidence for a location-specific gradient in intestinal feedback on food intake and GI peptide release. International Journal of Obesity, 41(2), 217-224. https://doi.org/10.1038/ijo.2016.196
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  • van Avesaat, M., Troost, F., Ripken, D., Peters, J., Hendriks, H. F., & Masclee, A. A. (2015). Intraduodenal infusion of a combination of tastants decreases food intake in humans. American Journal of Clinical Nutrition, 102(4), 729-735. https://doi.org/10.3945/ajcn.115.113266
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  • Salden, B., Monserrat, V., Troost, F. J., Bruins, M. J., Edens, L., Bartholomé, R., Haenen, G. R., Winkens, B., Koning, F., & Masclee, A. A. (2015). Randomised clinical study: Aspergillus niger-derived enzyme digests gluten in the stomach of healthy volunteers. Alimentary Pharmacology & Therapeutics, 42(3), 273-285. https://doi.org/10.1111/apt.13266
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  • Mujagic, Z., de Vos, P., Boekschoten, M. V., Govers, C., Pieters, H.-J. H. M., de Wit, N. J. W., Bron, P. A., Masclee, A. A. M., & Troost, F. J. (2017). The effects of Lactobacillus plantarum on small intestinal barrier function and mucosal gene transcription; a randomized double-blind placebo controlled trial. Scientific Reports, 7, Article 40128. https://doi.org/10.1038/srep40128
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Recent publications
  • Cuijpers, I., Sthijns, M. M. J. P. E., van den Bogart, V. A. R., Katsburg, J., Leenders, C. F. M., & Troost, F. J. (2025). Quercetin, Kaempferol and Capsaicin Counteract the TGF-ß1-Induced Upregulation of aSMA and Collagen in Myoblasts. International Journal of Molecular Sciences, 26(11), Article 5151. https://doi.org/10.3390/ijms26115151
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  • Cuijpers, I., Katsburg, J., van Loon, L. J. C., Troost, F. J., & Sthijns, M. M. J. P. E. (2025). Nutritional strategies targeting age-related skeletal muscle fibrosis: underlying mechanisms. Critical Reviews in Food Science and Nutrition, 1-21. https://doi.org/10.1080/10408398.2025.2498676
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  • An, R., Wilms, E., Gerritsen, J., Kim, H. K., Perez, C. S., Besseling-van der Vaart, I., Jonkers, D. M. A. E., Rijkers, G. T., de Vos, W. M., Masclee, A. A. M., Zoetendal, E. G., Troost, F. J., & Smidt, H. (2024). Spatio-temporal dynamics of the human small intestinal microbiome and its response to a synbiotic. Gut Microbes, 16(1), Article 2350173. https://doi.org/10.1080/19490976.2024.2350173
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  • Wilbrink, J., van Avesaat, M., Stronkhorst, A., Troost, F., le Roux, C. W., & Masclee, A. (2024). Peptide YY and Glucagon-like Peptide-1 Secretion in Obesity. Gastrointestinal Disorders, 7(1), Article 3. https://doi.org/10.3390/gidisord7010003
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  • Neuen, S. M. L., Ophelders, D. R. M. G., Widowski, H., Hütten, M. C., Brokken, T., van Gorp, C., Nikkels, P. G. J., Severens-Rijvers, C. A. H., Sthijns, M. M. J. P. E., van Blitterswijk, C. A., Troost, F. J., LaPointe, V. L. S., Jolani, S., Seiler, C., Pillow, J. J., Delhaas, T., Reynaert, N. L., & Wolfs, T. G. A. M. (2024). Multipotent adult progenitor cells prevent functional impairment and improve development in inflammation driven detriment of preterm ovine lungs. Regenerative Therapy, 27, 207-217. https://doi.org/10.1016/j.reth.2024.03.014
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  • Imperatrice, M., Lasfar, A., van Kalkeren, C. A. J., & Troost, F. (2024). Olive Leaf Extract Supplementation Improves Postmenopausal Symptoms: A Randomized, Double-Blind, Placebo-Controlled Parallel Study on Postmenopausal Women. Nutrients, 16(22), Article 3879. https://doi.org/10.3390/nu16223879
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  • Dayon, L., Núñez Galindo, A., Chevalier, J., Aquarius, M., Otten, B., Troost, F. J., Duncan, P., & Affolter, M. (2024). Detection of gluten peptides in human duodenal fluids with immuno-liquid chromatography-mass spectrometry. Analytical methods, 16(40), 6819-6828. https://doi.org/10.1039/d4ay00852a
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  • van Gorp, C., de Lange, I. H., Hutten, M. C., Lopez-Iglesias, C., Massy, K. R. I., Kessels, L., Knoops, K., Cuijpers, I., Sthijns, M. M. J. P. E., Troost, F. J., van Gemert, W. G., Spiller, O. B., Birchenough, G. M. H., Zimmermann, L. J. I., & Wolfs, T. G. A. M. (2024). Antenatal Ureaplasma Infection Causes Colonic Mucus Barrier Defects: Implications for Intestinal Pathologies. International Journal of Molecular Sciences, 25(7), Article 4000. https://doi.org/10.3390/ijms25074000
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  • Cuijpers, I., Dohmen, C. G. M., Bouwman, F. G., Troost, F. J., & Sthijns, M. M. J. P. E. (2024). Hesperetin but not ellagic acid increases myosin heavy chain expression and cell fusion in C2C12 myoblasts in the presence of oxidative stress. Frontiers in nutrition, 11, Article 1377071. https://doi.org/10.3389/fnut.2024.1377071
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  • Zaccaria, E., Klaassen, T., Alleleyn, A. M. E., Boekhorst, J., Chervaux, C., Smokvina, T., Troost, F. J., & Kleerebezem, M. (2023). L. rhamnosus CNCM I-3690 survival, adaptation, and small bowel microbiome impact in human. Gut microbes, 15(1), Article 2244720. https://doi.org/10.1080/19490976.2023.2244720
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