PhD Defence Siyu Sun

Supervisor: Prof. dr. Johan W. M. Heemskerk

Co-supervisors: Dr. Bas de Laat, Dr. Mark Roest

Keywords: Thrombin, platelets, red blood cells, fibrin
 

"Platelets, Red Blood Cells, Fibrinogen and Endothelial Cells: Essential Components in Blood Clotting"
 

Blood clotting is essential for preventing excessive bleeding after an injury, but when the process is not properly controlled, it can lead to serious health issues such as thrombosis (dangerous blood clots) or excessive bleeding. This research focuses on understanding how blood clots form and the different factors that influence their stability. By studying the interactions between specific blood components, it aims to uncover new insights into how clotting is regulated and how it might be affected by medications or diseases. The goal is to improve knowledge of the body’s natural clotting mechanisms and identify potential ways to prevent or treat clotting disorders. The findings from this work could help develop better diagnostic tools and treatments for conditions where blood clots are either too weak or too strong, ultimately improving patient care and outcomes.

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