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A.I. Casas Guijarro

Recent publications
  • Casas, A. I., Nogales, C., Szepanowski, R. D., Elbatreek, M. H., Anastasi, E., Sadegh, S., Skelton, J., Frank, B., Wipat, A., Baumbach, J., Kleinschnitz, C., & Schmidt, H. H. H. W. (2025). Synergistic Network Pharmacology: Preclinical Validation and Clinical Safety in Acute Ischemic Stroke. Journal of the American Heart Association, 14(10), Article e039098. https://doi.org/10.1161/JAHA.124.039098
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  • Sedding, D., Schmidt, T. M., Bähre, H., Bavendiek, U., Casas, A. I., Chen, S., Thao-Vi Dao, V., Elbatreek, M. H., Gutzki, F., Hahn, A., Kleikers, P., Krahn, T., Macchiusi, C., Martin, C., Mucke, H., Nogales, C., Schmidt, B. M. L., Seifert, R., Sonnenschein, K., ... Schmidt, H. H. H. W. (2025). Nutritional L-Citrulline and Tetrahydrobiopterin in Peripheral Artery Disease: A Phase II Randomized Trial (CIPER Study). JACC: Advances, 4(3), Article 101590. https://doi.org/10.1016/j.jacadv.2025.101590
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  • Grønning, A. G., Vonhof, S. E., Elbatreek, M., Hamker, A., Szepanowski, R. D., Erkelenz, S. C., Langhauser, F., Egea, J., Lopez, M. G., Baumbach, J., Kleinschnitz, C., & Casas, A. I. (2025). Unveiling the interplay between soluble guanylate cyclase activation and redox signalling in stroke pathophysiology and treatment. Biomedicine & Pharmacotherapy, 183, Article 117829. https://doi.org/10.1016/j.biopha.2025.117829
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  • Haupeltshofer, S., Steinbach, P., Wenzek, C., Szepanowski, R. D., Mausberg, A. K., Blusch, A., Hansmann, C., Casas, A. I., Hansen, W., Westendorf, A. M., Knuschke, T., Langhauser, F., & Kleinschnitz, C. (2025). Influenza A Infection Increases Severity of Acute Ischemic Stroke Through Neutrophil Activation and Hypercoagulability. Stroke. Advance online publication. https://doi.org/10.1161/STROKEAHA.125.052967
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  • Haupeltshofer, S., Mencl, S., Szepanowski, R. D., Hansmann, C., Casas, A. I., Abberger, H., Hansen, W., Blusch, A., Deuschl, C., Forsting, M., Hermann, D. M., Langhauser, F., & Kleinschnitz, C. (2024). Delayed plasma kallikrein inhibition fosters post-stroke recovery by reducing thrombo-inflammation. Journal of Neuroinflammation, 21(1), Article 155. https://doi.org/10.1186/s12974-024-03149-w
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  • Maier, A., Rafiei, M., Anastasi, E., Zolotareva, O., Skelton, J., Elkjaer, M. L., Casas, A. I., Nogales, C., Schmidt, H. H. H. W., Kacprowski, T., Blumenthal, D. B., Wipat, A., Sadegh, S., & Baumbach, J. (2024). NeDRex-Web: An Interactive Web Tool for Drug Repurposing by Exploring Heterogeneous Molecular Networks. In M. Cannataro, H. Zheng, L. Gao, J. Cheng, J. L. de Miranda, E. Zumpano, X. Hu, Y.-R. Cho, & T. Park (Eds.), Proceedings - 2024 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2024 (pp. 429-434). IEEE. https://doi.org/10.1109/BIBM62325.2024.10822390
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  • Pacheco Pachado, M., Casas, A. I., Elbatreek, M. H., Nogales, C., Guney, E., Espay, A. J., & Schmidt, H. H. H. W. (2023). Re-Addressing Dementia by Network Medicine and Mechanism-Based Molecular Endotypes. Journal of Alzheimer's Disease, 96(1), 47-56. Article 230694. https://doi.org/10.3233/JAD-230694
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  • Palomino-Antolín, A., Decouty-Pérez, C., Farré-Alins, V., Narros-Fernández, P., Lopez-Rodriguez, A. B., Álvarez-Rubal, M., Valencia, I., López-Muñoz, F., Ramos, E., Cuadrado, A., Casas, A. I., Romero, A., & Egea, J. (2023). Redox Regulation of Microglial Inflammatory Response: Fine Control of NLRP3 Inflammasome through Nrf2 and NOX4. Antioxidants, 12(9), Article 1729. https://doi.org/10.3390/antiox12091729
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  • Szepanowski, R. D., Haupeltshofer, S., Vonhof, S. E., Frank, B., Kleinschnitz, C., & Casas, A. (2023). Thromboinflammatory challenges in stroke pathophysiology. Seminars in Immunopathology, 45(3), 389-410. https://doi.org/10.1007/s00281-023-00994-4
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  • Petraina, A., Elbatreek, M., Neullens, C. T., Saridaki, T., Dao, V. T.-V., Casas Guijarro, A., & Schmidt, H. (2023). Understanding (apo-) soluble guanylate cyclase allosterism and its therapeutic implications. DrugRxiv. https://doi.org/10.14293/S2199-1006.1.SOR-.PPW9FFL.v2
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