ing R.L.H.M.G. Spätjens

Schwartz, P. J., Moreno, C., Kotta, M.-C., Pedrazzini, M., Crotti, L., Dagradi, F., Castelletti, S., Haugaa, K. H., Denjoy, I., Shkolnikova, M. A., Brink, P. A., Heradien, M. J., Seyen, S. R. M., Spätjens, R. L. H., Spazzolini, C., & Volders, P. G. A. (2021). Mutation location and I-Ks requlation in the arrhythmic risk of long QT syndrome type 1: the importance of the KCNQ1 S6 region. European Heart Journal, 42(46), 4743-4755. https://doi.org/10.1093/eurheartj/ehab582

Altrocchi, C., de Korte, T., Bernardi, J., Spätjens, R. L. H., Braam, S. R., Heijman, J., Zaza, A., & Volders, P. G. A. (2020). Repolarization instability and arrhythmia by I-Kr block in single human-induced pluripotent stem cell-derived cardiomyocytes and 2D monolayers. EP Europace, 22(9), 1431-1441. https://doi.org/10.1093/europace/euaa111

Spätjens, R. L. H., Bebarova, M., Seyen, S. R. M., Lentink, V., Jongbloed, R. J., Arens, Y. H. J. M., Heijman, J., & Volders, P. G. A. (2014). Long-QT mutation p.K557E-Kv7.1: dominant-negative suppression of I-Ks, but preserved cAMP-dependent up-regulation. Cardiovascular Research, 104(1), 216-225. https://doi.org/10.1093/cvr/cvu191

Molina, C. E., Johnson, D. M., Mehel, H., Spätjens, R. L. H., Mika, D., Algalarrondo, V., Slimane, Z. H., Lechene, P., Abi-Gerges, N., van der Linde, H. J., Leroy, J., Volders, P. G. A., Fischmeister, R., & Vandecasteele, G. (2014). Interventricular Differences in beta-Adrenergic Responses in the Canine Heart: Role of Phosphodiesterases. Journal of the American Heart Association, 3(3), Article e000858. https://doi.org/10.1161/JAHA.114.000858

Heijman, J., Spätjens, R. L. H., Seyen, S. R. M., Lentink, V., Kuijpers, H. J. H., Boulet, I. R., de Windt, L. J., David, M., & Volders, P. G. A. (2012). Dominant-Negative Control of cAMP-Dependent I-Ks Upregulation in Human Long-QT Syndrome Type 1. Circulation Research, 110(2), 211–219. https://doi.org/10.1161/CIRCRESAHA.111.249482

Donker, D. W., Maessen, J. G., Spätjens, R. L. H., van der Nagel, T., de Jong, M. M., Ramaekers, F. C., Crijns, H. J. G. M., Vos, M. A., & Volders, P. G. A. (2007). Serial left-ventricular biopsy sampling using a minimally invasive trans-thoracic approach in adult dogs. Pflugers Archiv-European Journal of Physiology, 454(6), 1043-1051. https://doi.org/10.1007/s00424-007-0261-z

Donker, D. W., Maessen, J. G., Verheyen, F., Ramaekers, F., Spätjens, R. L. H., Kuijpers, R., Rarnakers, C., Schiffers, P. M. H., Vos, M. A., Crijns, H. J. G. M., & Volders, P. G. A. (2007). Impact of acute and enduring volume overload on mechanotransduction and cytoskeletal integrity of canine left ventricular myocardium. American Journal of Physiology-heart and Circulatory Physiology, 292(5), H2324-H2332. https://doi.org/10.1152/ajpheart.00392.2006

Stengl, M., Ramakers, C., Donker, D. W., Nabar, A., Rybin, A. V., Spätjens, R. L. H., van der Nagel, T., Wodzig, W., Sipido, K. R., Antoons, G., Moorman, A. F. M., Vos, M. A., & Volders, P. G. A. (2006). Temporal patterns of electrical remodeling in canine ventricular hypertrophy: Focus on I-Ks downregulation and blunted beta-adrenergic activation. Cardiovascular Research, 72(1), 90-100. https://doi.org/10.1016/j.cardiores.2006.07.015

Donker, D. W., Volders, PGA., Arts, T., Bekkers, BBACM., Hofstra, L., Spätjens, R. L. H., Beekman, J. D. M., Borgers, M., Crijns, HJGM., & Vos, MA. (2005). End-diastolic myofiber stress and ejection strain increase with ventricular volume overload. Basic Research in Cardiology, 100(4), 372-382. https://doi.org/10.1007/s00395-005-0525-8

Ramakers, C., Stengl, M., Spätjens, R. L. H., Moorman, A. F. M., & Vos, MA. (2005). Molecular and electrical characterization of the canine cardiac ventricular septum. Journal of Molecular and Cellular Cardiology, 38(1), 153-161. https://doi.org/10.1016/j.yjmcc.2004.10.011