Dr. Masoud Zamani Esteki

Associate professor
Head of the Laboratory of Cellular Genomic Medicine

Single-cell omics, Reproductive Genetics, Genomic Medicine, Artificial intelligence 

Laboratory of Cellular Genomic Medicine
Department of Clinical Genetics
Maastricht UMC+
6202 AZ Maastricht

E: masoud.zamaniesteki@mumc.nl
T: +31 43 38 75306 / secretary: +31 43 38 71272-3
Science & Innovation: www.zamanilab.org CGM to tackle reproductive odds
Science & Societywww.pre-health.org PREhealth to enhane reproductive literacy

Laboratory of Cellular Genomic Medicine

Head of the Laboratory of Cellular Genomic Medicine
Dr. Masoud Zamani Esteki

Honors and awards

2022     The Royal Academy of Arts and Sciences (KNAW) young investigator award, NL 
2019     Travel grant winner and Finalist for the Joe Leigh Simpson Award for the Best Early Career Investigator, International Society of Prenatal Diagnosis and Therapy (ISPD)
2015     Winner of the International Royan Award for outstanding research in Reproductive Genetics, Tehran
2015     Trainee Paper Spotlight for outstanding publication and research done by trainee members of ASHG
2014     Awarded for the best oral presentation in basic research at PGDIS 2014, Kent, UK
2014     Winner of Charles J. Epstein Trainee Award for Excellence in Human Genetics Research, San Diego, USA
2014     Candidate for the Young Investigator Awards of the ESHG 2014 Conference, Milan, Italy
2012     Nominated for the Royan International award, Tehran, Iran
2012     Travel grant for the Royan International Twin Congress, Tehran, Iran
2011    Winner of the European Society of Human Genetics (ESHG) fellowship for 4th Course in Integration of cytogenetics, microarray and massive sequencing in biomedical and clinical research, Bologna, Italy

Selected publications

  • Zamani Esteki, M. The effect of embryonic genome imbalances on pregnancy. (2023). Nature Medicine. doi:10.1038/s41591-023-02687-9. PMID: 38012316.
  • ​Essers, R., Lebedev, I., Kurg, A., Fonova, EA., Stevens, S.J.C., Koeck, RM., von Rango, U., Brandts, L., Panagiotis Deligiannis, S., Nikitina, TV., Sazhenova, EA., Tolmacheva, EN., Kashevarova, AA., Fedotov, DA., Demeneva, VV., Zhigalina, DI., Drozdov, GV., Al-Nasiry, S., Macville, M.V. E., van den Wijngaard, A., Dreesen, J., Paulussen, A., Hoischen, A., Brunner, HG., Salumets S., Zamani Esteki, M. The nature and prevalence of chromosomal alterations in first-trimester spontaneous pregnancy loss. (2023). Nature Medicine. doi: 10.1038/s41591-023-02645-5. PMID: 37996709.
  • ​Pathare, ADS., Loid, M., Saare M., Brusell, Gidlöf S., Zamani Esteki M., Acharya, G., Peters, M., Salumets, A. Endometrial receptivity in women of advanced age – an underrated factor in infertility. (2023). Human Reproduction Update. doi: 10.1093/humupd/dmad019. PMID: 37468438.
  • Vernimmen, V., Paulussen, ADC., Dreesen, JCFM., van Golde, RJ., Zamani Esteki, M., Coonen, E., van Buul-van Zwet, ML., Homminga, I., Derijck, AAHA., Brandts, L., Stumpel, CTRM., de Die-Smulders, CEM. Preimplantation genetic testing for Neurofibromatosis type 1: more than 20 years of clinical experience. (2023). European Journal of Human Genetics. doi: 10.1038/s41431-023-01404-x. PMID: 37337089.
  • *Stevens Brentjens, LBPM., *Obukhova, D., den Hartog, JE., Delvoux, B., Koskivuori, J., Auriola, S., Häkkinen, MR., Bui BN., van Hoogenhuijze, NE., Mackens, S., Mol, F., de Bruin, JP., Besselink, D., Teklenburg, G., Kukushkina, V., Salumets, A., Broekmans, FJM., van Golde, RJT., #Zamani Esteki, M., #Romano A. An integrative analysis of endometrial steroid metabolism and transcriptome in relation to endometrial receptivity in in vitro fertilization patients. (2023). Fertility and Sterility Science. doi: 10.1016/j.xfss.2023.04.003.  PMID: 37142054 
    *Co-first author #Co-last author
  • Van Dijk, W., Derks, K., Drüsedau, M., Meekels, J., Koeck, R., Essers, R., Dreesen, J., Coonen, E., de Die-Smulders, CEM., van Wijngaard, A., Paulussen, ADC., Zamani Esteki, M.  Embryo Tracking System for High-throughput Sequencing-based Preimplantation Genetic Testing. (2022). Human Reproduction. doi: 10.1093/humrep/deac208. PMID: 36149256.
  • Koeck, R., Busato, F., Tost, J., Consten, D., Zandstra, H., Remy, S., Langie, S. , Gielen, M., van Golde, R., Dumoulin, JCM., Brunner, HG., #Zamani Esteki, M., #van Montfoort, APA. At age 9 the methylome of assisted reproductive technology children that underwent embryo culture in different media is not significantly different on a genome-wide scale. (2022). Human Reproduction. doi: 10.1093/humrep/deac213. PMID: 36206092  
    #Co-senior/corresponding author
  • Koeck, R., Busato, F., Tost, J., Consten, D., van Echten-Arends, J., Mastenbroek, S., Wurth, Y., Gielen, M., van Golde, R., Dumoulin, JCM., Brunner, HG., #van Montfoort, APA., #Zamani Esteki, M. Methylome-wide analysis of IVF neonates that underwent embryo culture in different media revealed no significant differences. (2022). npj Genomic Medicine. doi: 10.1038/s41525-022-00310-3. PMID: 35768464.
    #Co-senior/corresponding author
  • Heesterbeek, CJ., Aukema, SM, Galjaard, RH., Boon, EMJ., Srebniak, MI., Bouman, K., Faas, BHW., Govaerts, LCP., Hoffer, MJV.,  den Hollander, NS., Lichtenbelt, KD., van Maarle, MC., van Prooyen Schuurman, L., van Rij, MC.,  Schuring-Blom, GH., Stevens, SJC., Tan-Sindhunata, G., Zamani Esteki, M., de Die-Smulders, CEM., Tjan-Heijnen, VCG., Henneman, L., Sistermans, EA., Macville, MVE., Dutch NIPT Consortium. (2022). Prenatal Test Results Indicative of Maternal Malignancies: A Nationwide Genetic and Clinical Follow-Up Study. Journal of Clinical Oncology. doi: 10.1200/JCO.21.02260. PMID: 35394817
  • Masset, H., Ding, J., Dimitriadou, E., Debrock, S., Tšuiko, O., Smits, K., Peeraer, K., Voet, T., Zamani Esteki, M., Vermeesch, JR. (2022). Single-cell genome-wide concurrent haplotyping and copy-number profiling through genotyping-by-sequencing. Nucleic Acids Research, doi: 10.1093/nar/gkac134. PMID: 35212381
  • *Schobers, G., *Koeck, R., Pellaers, D., Stevens, S., Macville, M., Paulussen, ADC., Coonen, E., van Wijngaard, A., de Die-Smulders, CEM., De Wert, G., Brunner, HG., and Zamani Esteki, M. (2021). Liquid biopsy: State of Reproductive Medicine and Beyond. Human Reproduction,  doi: 10.1093/humrep/deab206. PMID: 34562078 *Co-first authors
  • Sallevelt SCEH, Stegmann APA, de Koning, B., Velter  C., Steyls  A., van Esch  M., Lakeman P., Yntema H., Zamani Esteki, M., de Die-Smulders CEM., Gilissen  C., van den Wijngaard A., Brunner HG., Paulussen ADC.  Diagnostic exome-based preconception carrier testing in consanguineous couples: results from the first 100 couples in clinical practice. (2021). Genetics in Medicine, 23(6):1125-1136. doi: 10.1038/s41436-021-01116-x. PMID: 33742171
  • Che, H., Villela, D., Dimitriadou, E., Melotte, C., Brison, N., Neofytou, M., Van Den Bogaert, K., Tsuiko, O., Devriendt, K., Legius, E., Zamani Esteki, M., Voet, T., Vermeesch, JR. Noninvasive prenatal diagnosis by genome-wide haplotyping of cell-free plasma DNA. (2020). Genetics in Medicine, 22(5):962-973. doi: 10.1038/s41436-019-0748-y. PMID: 32024963
  • Ding, J., Dimitriadou, E., Tsuiko, O., Destouni, A., Melotte, C., Van Den Bogaert, K., Debrock, S., Jatsenko, T., Zamani Esteki, M., Voet, T., Peeraer, K., Denayer, E., Vermeesch, J.R. (2020). Identity-by-state-based haplotyping expands the application of comprehensive preimplantation genetic testing. Human Reproduction, 35 (3), 718-726. doi: 10.1093/humrep/dez285. PMID: 32198505
  • Zamani Esteki, M.#,*, Viltrop T.*, Tšuiko, O.*, Tiirats, A. Koel, M., Nõukas M., Žilina, O., Heearu, K.,Marjonen, H., Kahila, H., Meekels, J., Söderström-Anttila, V., Suikkari, A., Mägi, R., Kõks, S.,Kaminen-Ahola, N., Kurg, A., Voet, T.#, Vermeesch JR# and Salumets, A#. In vitro fertilization does not increase the incidence of de novo copy number alterations in fetal and placental lineages. (2019). Nature Medicine, 25(11):1699-1705. doi: 10.1038/s41591-019-0620-2. PMID: 31686035
    *Joint first author, #Co-senior/corresponding author


Haplotyping and copy number typing by polymorphic variant allele frequencies. (2015) ZL913096 - PCT/EP2014/068315 - WO/2015/028576
Methods for haplotyping single cells. (2011) ZL910050 -PCT/EP2011/060211 - WO/2011/157846

Full list of publications

For Full list of publications see:

Laboratory of Cellular Genomic Medicine

Genetics in Early Human Development

Maastricht IVF: IVF has no detrimental effect on the genome of fetal and placenta lineages

Masoud and his team showed that chromosome instability is not preserved at birth and IVF has no detrimental effect on the genome of IVF children.

Masoud receives the Dutch Royal Academy award

We are proud to share that our researcher Masoud Zamani Esteki is one of the 12 researchers receiving the KNAW Early Career Award.