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H.H.H.W. Schmidt

Research projects

COST action OpenMultiMed

H2020 FeatureCloud

H2020 REPO-TRIAL

ERC PoC SAVEBRAI

Key publications
  • Langhauser, F., Casas, A. I., Dao, V.-T.-V., Guney, E., Menche, J., Geuss, E., Kleikers, P. W. M., López, M. G., Barabási, A.-L., Kleinschnitz, C., & Schmidt, H. H. H. W. (2018). A diseasome cluster-based drug repurposing of soluble guanylate cyclase activators from smooth muscle relaxation to direct neuroprotection. NPJ systems biology and applications, 4(1), Article 8. https://doi.org/10.1038/s41540-017-0039-7
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  • Casas, A. I., Geuss, E., Kleikers, P. W. M., Mencl, S., Herrmann, A. M., Buendia, I., Egea, J., Meuth, S. G., Lopez, M. G., Kleinschnitz, C., & Schmidt, H. H. H. W. (2017). NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage. Proceedings of the National Academy of Sciences of the United States of America, 114(46), 12315-12320. https://doi.org/10.1073/pnas.1705034114
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  • Aguirre-Plans, J., Pinero, J., Menche, J., Sanz, F., Furlong, L. I., Schmidt, H. H. H. W., Oliva, B., & Guney, E. (2018). Proximal Pathway Enrichment Analysis for Targeting Comorbid Diseases via Network Endopharmacology. Pharmaceuticals, 11(3), Article 61. https://doi.org/10.3390/ph11030061
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  • Gray, S. P., Jha, J. C., Kennedy, K., van Bommel, E., Chew, P., Szyndralewiez, C., Touyz, R. M., Schmidt, H. H. H. W., Cooper, M. E., & Jandeleit-Dahm, K. A. M. (2017). Combined NOX1/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease. Diabetologia, 60(5), 927-937. https://doi.org/10.1007/s00125-017-4215-5
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  • Kleinschnitz, C., Mencl, S., Kleikers, P. W. M., Schuhmann, M. K., Lopez, M. G., Casas, A. I., Surun, B., Reif, A., & Schmidt, H. H. H. W. (2016). NOS knockout or inhibition but not disrupting PSD-95-NOS interaction protect against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 36(9), 1508-1512. https://doi.org/10.1177/0271678X16657094
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  • Gray, S. P., Di Marco, E., Kennedy, K., Chew, P., Okabe, J., El-Osta, A., Calkin, A. C., Biessen, E. A. L., Touyz, R. M., Cooper, M. E., Schmidt, H. H. H. W., & Jandeleit-Dahm, K. A. M. (2016). Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular Remodeling. Arteriosclerosis Thrombosis and Vascular Biology, 36(2), 295-307. https://doi.org/10.1161/ATVBAHA.115.307012
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  • Casas, A. I., Dao, V. T.-V., Daiber, A., Maghzal, G. J., Di Lisa, F., Kaludercic, N., Leach, S., Cuadrado, A., Jaquet, V., Seredenina, T., Krause, K. H., Lopez, M. G., Stocker, R., Ghezzi, P., & Schmidt, H. H. H. W. (2015). Reactive Oxygen-Related Diseases: Therapeutic Targets and Emerging Clinical Indications. Antioxidants & Redox Signaling, 23(14), 1171-1185. https://doi.org/10.1089/ars.2015.6433
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  • Kleikers, P. W. M., Hooijmans, C., Goeb, E., Langhauser, F., Rewell, S. S. J., Radermacher, K., Ritskes-Hoitinga, M., Howells, D. W., Kleinschnitz, C., & Schmidt, H. H. H. W. (2015). A combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validation. Scientific Reports, 5, Article 13428. https://doi.org/10.1038/srep13428
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  • Kleinschnitz, C., Grund, H., Wingler, K., Armitage, M. E., Jones, E., Mittal, M., Barit, D., Schwarz, T., Geis, C., Kraft, P., Barthel, K., Schuhmann, M. K., Herrmann, A. M., Meuth, S. G., Stoll, G., Meurer, S., Schrewe, A., Becker, L., Gailus-Durner, V., ... Schmidt, H. H. H. W. (2010). Post-Stroke Inhibition of Induced NADPH Oxidase Type 4 Prevents Oxidative Stress and Neurodegeneration. Plos Biology, 8(9), Article e1000479. https://doi.org/10.1371/journal.pbio.1000479
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  • Frijhoff, J., Winyard, P. G., Zarkovic, N., Davies, S. S., Stocker, R., Cheng, D., Knight, A. R., Taylor, E. L., Oettrich, J., Ruskovska, T., Gasparovic, A. C., Cuadrado, A., Weber, D., Poulsen, H. E., Grune, T., Schmidt, H. H. H. W., & Ghezzi, P. (2015). Clinical Relevance of Biomarkers of Oxidative Stress. Antioxidants & Redox Signaling, 23(14), 1144-1170. https://doi.org/10.1089/ars.2015.6317
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Recent publications
  • Casas, A. I., Nogales, C., Szepanowski, R. D., Elbatreek, M. H., Anastasi, E., Sadegh, S., Skelton, J., Frank, B., Wipat, A., Baumbach, J., Kleinschnitz, C., & Schmidt, H. H. H. W. (2025). Synergistic Network Pharmacology: Preclinical Validation and Clinical Safety in Acute Ischemic Stroke. Journal of the American Heart Association, 14(10), Article e039098. https://doi.org/10.1161/JAHA.124.039098
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  • Sedding, D., Schmidt, T. M., Bähre, H., Bavendiek, U., Casas, A. I., Chen, S., Thao-Vi Dao, V., Elbatreek, M. H., Gutzki, F., Hahn, A., Kleikers, P., Krahn, T., Macchiusi, C., Martin, C., Mucke, H., Nogales, C., Schmidt, B. M. L., Seifert, R., Sonnenschein, K., ... Schmidt, H. H. H. W. (2025). Nutritional L-Citrulline and Tetrahydrobiopterin in Peripheral Artery Disease: A Phase II Randomized Trial (CIPER Study). JACC: Advances, 4(3), Article 101590. https://doi.org/10.1016/j.jacadv.2025.101590
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  • Scholte, M., Grimm, S. E., Pauly, B., Verbeeck, F., Pasmooij, A. M. G., Bouma, B., van Duijn-Wiersma, J., Guney, E., Kesselheim, A. S., Schmidt, H. H. H. W., & Joore, M. A. (2025). Revising EU pharmaceutical legislation: will it foster drug repurposing? Drug Discovery Today, 30(1), Article 104286. https://doi.org/10.1016/j.drudis.2024.104286
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  • Maier, A., Rafiei, M., Anastasi, E., Zolotareva, O., Skelton, J., Elkjaer, M. L., Casas, A. I., Nogales, C., Schmidt, H. H. H. W., Kacprowski, T., Blumenthal, D. B., Wipat, A., Sadegh, S., & Baumbach, J. (2024). NeDRex-Web: An Interactive Web Tool for Drug Repurposing by Exploring Heterogeneous Molecular Networks. In M. Cannataro, H. Zheng, L. Gao, J. Cheng, J. L. de Miranda, E. Zumpano, X. Hu, Y.-R. Cho, & T. Park (Eds.), Proceedings - 2024 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2024 (pp. 429-434). IEEE. https://doi.org/10.1109/BIBM62325.2024.10822390
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  • Pacheco Pachado, M., Casas, A. I., Elbatreek, M. H., Nogales, C., Guney, E., Espay, A. J., & Schmidt, H. H. H. W. (2023). Re-Addressing Dementia by Network Medicine and Mechanism-Based Molecular Endotypes. Journal of Alzheimer's Disease, 96(1), 47-56. Article 230694. https://doi.org/10.3233/JAD-230694
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  • Alexander, S. P. H., Fabbro, D., Kelly, E., Mathie, A. A., Peters, J. A., Veale, E. L., Armstrong, J. F., Faccenda, E., Harding, S. D., Davies, J. A., Beuve, A., Brouckaert, P., Bryant, C., Burnett, J. C., Farndale, R. W., Friebe, A., Garthwaite, J., Hobbs, A. J., Jarvis, G. E., ... Waldman, S. A. (2023). The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. British Journal of Pharmacology, 180(S2), S241-S288. https://doi.org/10.1111/bph.16180
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  • Matschinske, J., Spaeth, J., Bakhtiari, M., Probul, N., Majdabadi, M. M. K., Nasirigerdeh, R., Torkzadehmahani, R., Hartebrodt, A., Orban, B.-A., Fejer, S.-J., Zolotareva, O., Das, S., Baumbach, L., Pauling, J. K., Tomasevic, O., Bihari, B., Bloice, M., Donner, N. C., Fdhila, W., ... Baumbach, J. (2023). The FeatureCloud Platform for Federated Learning in Biomedicine: Unified Approach. Journal of Medical Internet Research, 25(1), Article e42621. https://doi.org/10.2196/42621
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  • Petraina, A., Elbatreek, M., Neullens, C. T., Saridaki, T., Dao, V. T.-V., Casas Guijarro, A., & Schmidt, H. (2023). Understanding (apo-) soluble guanylate cyclase allosterism and its therapeutic implications. DrugRxiv. https://doi.org/10.14293/S2199-1006.1.SOR-.PPW9FFL.v2
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  • Mohamed Mamdouh Abdelkareem Gomaa, Z., Anastasi, E., Hassan, A., Boltze, J., Elbatreek, M., Nogales Calvo, C., Pacheco Pachado, M., Petraina, A., Piper, Z., Rodriguez Gonzalez, A., Wipat, A., Silverman, E., Casas Guijarro, A., Guney, E., Schmidt, H., REPO-TRIAL, & REPO4EU consortia (2023). Why the way we define diseases prevents innovation and precision medicine. DrugRxiv. https://doi.org/10.14293/S2199-1006.1.SOR-.PPCFYDY.v1
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  • Petraina, A., Elbatreek, M., Neullens, C. T., Saridaki, T., Dao, V. T.-V., Casas Guijarro, A., & Schmidt, H. (2023). On a revised pharmacology of apo-soluble guanylate cyclase and its therapeutic implications. DrugRxiv. https://doi.org/10.14293/S2199-1006.1.SOR-.PPW9FFL.v1
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Publications ResearcherID

https://www.researchgate.net/profile/Harald_Schmidt?ev=hdr_xprf https://unimaas.academia.edu/HaraldHHWSchmidt