H.H.H.W. Schmidt
Onderzoeksprojecten
COST action OpenMultiMed
H2020 FeatureCloud
H2020 REPO-TRIAL
ERC PoC SAVEBRAIN
Key publicaties
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Langhauser, F., Casas, A. I., Dao, V.-T.-V., Guney, E., Menche, J., Geuss, E., Kleikers, P. W. M., López, M. G., Barabási, A.-L., Kleinschnitz, C., & Schmidt, H. H. H. W. (2018). A diseasome cluster-based drug repurposing of soluble guanylate cyclase activators from smooth muscle relaxation to direct neuroprotection. NPJ systems biology and applications, 4(1), Article 8. https://doi.org/10.1038/s41540-017-0039-7Meer informative over deze publicatie
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Casas, A. I., Geuss, E., Kleikers, P. W. M., Mencl, S., Herrmann, A. M., Buendia, I., Egea, J., Meuth, S. G., Lopez, M. G., Kleinschnitz, C., & Schmidt, H. H. H. W. (2017). NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage. Proceedings of the National Academy of Sciences of the United States of America, 114(46), 12315-12320. https://doi.org/10.1073/pnas.1705034114Meer informative over deze publicatie
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Aguirre-Plans, J., Pinero, J., Menche, J., Sanz, F., Furlong, L. I., Schmidt, H. H. H. W., Oliva, B., & Guney, E. (2018). Proximal Pathway Enrichment Analysis for Targeting Comorbid Diseases via Network Endopharmacology. Pharmaceuticals, 11(3), Article 61. https://doi.org/10.3390/ph11030061Meer informative over deze publicatie
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Gray, S. P., Jha, J. C., Kennedy, K., van Bommel, E., Chew, P., Szyndralewiez, C., Touyz, R. M., Schmidt, H. H. H. W., Cooper, M. E., & Jandeleit-Dahm, K. A. M. (2017). Combined NOX1/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease. Diabetologia, 60(5), 927-937. https://doi.org/10.1007/s00125-017-4215-5Meer informative over deze publicatie
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Kleinschnitz, C., Mencl, S., Kleikers, P. W. M., Schuhmann, M. K., Lopez, M. G., Casas, A. I., Surun, B., Reif, A., & Schmidt, H. H. H. W. (2016). NOS knockout or inhibition but not disrupting PSD-95-NOS interaction protect against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 36(9), 1508-1512. https://doi.org/10.1177/0271678X16657094Meer informative over deze publicatie
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Gray, S. P., Di Marco, E., Kennedy, K., Chew, P., Okabe, J., El-Osta, A., Calkin, A. C., Biessen, E. A. L., Touyz, R. M., Cooper, M. E., Schmidt, H. H. H. W., & Jandeleit-Dahm, K. A. M. (2016). Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular Remodeling. Arteriosclerosis Thrombosis and Vascular Biology, 36(2), 295-307. https://doi.org/10.1161/ATVBAHA.115.307012Meer informative over deze publicatie
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Casas, A. I., Dao, V. T.-V., Daiber, A., Maghzal, G. J., Di Lisa, F., Kaludercic, N., Leach, S., Cuadrado, A., Jaquet, V., Seredenina, T., Krause, K. H., Lopez, M. G., Stocker, R., Ghezzi, P., & Schmidt, H. H. H. W. (2015). Reactive Oxygen-Related Diseases: Therapeutic Targets and Emerging Clinical Indications. Antioxidants & Redox Signaling, 23(14), 1171-1185. https://doi.org/10.1089/ars.2015.6433Meer informative over deze publicatie
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Kleikers, P. W. M., Hooijmans, C., Goeb, E., Langhauser, F., Rewell, S. S. J., Radermacher, K., Ritskes-Hoitinga, M., Howells, D. W., Kleinschnitz, C., & Schmidt, H. H. H. W. (2015). A combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validation. Scientific Reports, 5, Article 13428. https://doi.org/10.1038/srep13428Meer informative over deze publicatie
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Kleinschnitz, C., Grund, H., Wingler, K., Armitage, M. E., Jones, E., Mittal, M., Barit, D., Schwarz, T., Geis, C., Kraft, P., Barthel, K., Schuhmann, M. K., Herrmann, A. M., Meuth, S. G., Stoll, G., Meurer, S., Schrewe, A., Becker, L., Gailus-Durner, V., ... Schmidt, H. H. H. W. (2010). Post-Stroke Inhibition of Induced NADPH Oxidase Type 4 Prevents Oxidative Stress and Neurodegeneration. Plos Biology, 8(9), Article e1000479. https://doi.org/10.1371/journal.pbio.1000479Meer informative over deze publicatie
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Frijhoff, J., Winyard, P. G., Zarkovic, N., Davies, S. S., Stocker, R., Cheng, D., Knight, A. R., Taylor, E. L., Oettrich, J., Ruskovska, T., Gasparovic, A. C., Cuadrado, A., Weber, D., Poulsen, H. E., Grune, T., Schmidt, H. H. H. W., & Ghezzi, P. (2015). Clinical Relevance of Biomarkers of Oxidative Stress. Antioxidants & Redox Signaling, 23(14), 1144-1170. https://doi.org/10.1089/ars.2015.6317Meer informative over deze publicatie