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… comes to rest on the ground, floor, or lower level’’.6 Annually, approximately one in three adults aged 65 years and older, and 50% of adults above the age of 80 years, experience a fall.7 In 2020, every five minutes an older adult in the Netherlands visited the emergency department due to a fall.8 Falls can have many adverse consequences, both on the individual as well as societal level, and are associated with functional decline, loss of autonomy, and reduced quality of life.9 In 2020, falls in … for a randomized controlled trial. BMC Neurol 2015;15:87. 40. Mansfield A, Schinkel‐Ivy A, Danells CJ et al. Does perturbation training prevent falls after discharge from stroke rehabilitation? A prospective cohort study with historical control. Paper presented at: 2016. Canadian Stroke Congress; 2016; Québec City, QC, Canada. 41. Marigold DS, Eng JJ, Dawson AS, Inglis JT, Harris JE, Gylfadottir S. Exercise leads to faster postural reflexes, improved balance and mobility, and fewer falls in … Randomization will be stratified based on sex (male versus female) and number of falls during the past year (1 versus 2 or more). This stratification will result in four different strata. The randomization sequence will be generated using an online random number generator. The allocation will be concealed by using sequentially numbered, sealed opaque envelopes. The person preparing the allocation concealment mechanism will be a different person than the one enrolling the subjects and …

… new scientific truth does not triumph by convincing its opponents and making them see the light, but rather because its opponents eventually die, and a new generation grows up that is familiar with it.” ― MAX PLANCK, SCIENTIFIC AUTOBIOGRAPHY AND OTHER PAPERS Parts of this dissertation were pre-published in: • Florea A, Morgenroth A, Bucerius J, Schurgers LJ, Mottaghy FM. Locking and loading the bullet against micro-calcification. Eur J Prev Cardiol. 2020;28(12):1370-1375. • Florea A, Sigl JP, … Statistical Analyses Plan ................................................................................... 99 5. Study Procedures ................................................................................................... 101 5.1. Hospital Visit .................................................................................................. 102 5.2. Na[18F]F PET/MRI ......................................................................................... 102 5.5. Laboratory Assessments … we describe a novel mouse model, which spontaneously develops spotty calcifications, detected by small animal CT, exclusively in the proximal aorta, with no apparent life-span reduction. – 84 – Supplementary Materials: The following are available online at www.mdpi.com/xxx/s1: Figure S1: Ulcerative dermatitis. Author Contributions: conceptualization, A.F., J.B., L.J.S., and F.M.M.; data curation, A.F. and O.H.W.; formal analysis, A.F. and J.P.S.; funding acquisition, J.B., L.J.S., and F.M.M.; …