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Sebastian Köhler (S.)

Research projects

- Main applicant en Co-PI Netherlands Dementia Prevention Initiative (NDPI)
- Work Package risk reduction in a memory clinic population as part of the national ABOARD consortium (www.aboard-project.nl)
- Co-PI Finger-NL lifestyle intervention trial as part of the national MOCIA consortium (www.mocia.nl)
- MijnBreincoach app for knowledge transfer on lifestyle and brain health (www.mijnbreincoach.eu)
- Public health campaign to promote a brain-healthy lifestyle (www.wezijnzelfhetmedicijn.nl)
- Management Board Member of The Maastricht Study (www.demaastrichtstudie.nl)
- Maastricht Aging Study (MAAS) into risk factors for cognitive decline in the general population (http://breinweb.nl/maas/)
- CASPER study into biomarkers for dementia and neuropsychiatric symptoms after stroke (https://www.alzheimercentrumlimburg.nl/2013-casper)
- Validation studies of the Lifestyle for Brain Health (LIBRA) index (https://www.alzheimercentrumlimburg.nl/2013-mindd)

Recent publications
  • Ruthmann, F., Lo, J. W., Mendyk-Bordet, A.-M., Allart, E., Köhler, S., Klimkowicz-Mrowiec, A., Staals, J., Sachdev, P. S., Bordet, R., Dondaine, T., & Stroke and Cognition (STROKOG) Collaboration (2025). Prevalence of poststroke anxiety and its associations with global cognitive impairment: An individual participant data analysis. Journal of Affective Disorders, 369, 1136-1144. https://doi.org/10.1016/j.jad.2024.10.099
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  • Van Asbroeck, S., Wimmers, S. C., van Boxtel, M. P. J., Groot Zwaaftink, R. B., Otten, V., Bekkenkamp, D., Köhler, S., & Deckers, K. (2025). Development and evaluation of a free e-learning program on dementia risk reduction for the general public: A pre-post study. Journal of Alzheimer's Disease, 103(4), 1075–1089. https://doi.org/10.1177/13872877241309112
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  • Van Asbroeck, S., Huque, M. H., Kootar, S., Peters, R., Cherbuin, N., Mortby, M. E., Köhler, S., van Boxtel, M. P. J., Deckers, K., & Anstey, K. J. (2025). Maintaining level of modifiable dementia risk scores is associated with better cognitive outcomes than increasing risk scores: A population-based prospective cohort study. JPAD-Journal of prevention of alzheimers disease, 12(1), Article 100014. https://doi.org/10.1016/j.tjpad.2024.100014
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  • Blake, J. J., Munyombwe, T., Fischer, F., Quinn, T. J., Van der Feltz-Cornelis, C. M., De Man-van Ginkel, J. M., Santos, I. S., Jeon, H. J., Köhler, S., Schram, M. T., Wang, J. L., Levin-Aspenson, H. F., Whooley, M. A., Hobfoll, S. E., Patten, S. B., Simning, A., Gracey, F., & Broomfield, N. M. (2025). The factor structure of the Patient Health Questionnaire-9 in stroke: A comparison with a non-stroke population. Journal of Psychosomatic Research, 188, Article 111983. https://doi.org/10.1016/j.jpsychores.2024.111983
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  • Soons, L. M., Deckers, K., Tange, H., van Boxtel, M. P. J., & Kohler, S. (2024). Associations of hearing and visual loss with cognitive decline and dementia risk: a 25-year follow-up of the Maastricht Aging Study. Age and Ageing, 53(12), Article afae271. https://doi.org/10.1093/ageing/afae271
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  • Sezer, B., Albers, J., Meisters, R., Schram, M. T., Köhler, S., Stehouwer, C. D. A., Koster, A., & Bosma, H. (2024). Do poor psychosocial resources mediate health inequalities in type 2 diabetes mellitus? Findings from the Maastricht study. European Journal of Public Health, 34(6), 1029-1035. Article ckae139. https://doi.org/10.1093/eurpub/ckae139
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  • Beran, M., Jansen, W. J., Oomens, J. E., Moonen, J. E. F., Slagboom, P. E., Huisman, M., Kok, A. A. L., Nooyens, A. C. J., Verschuren, W. M. M., Stehouwer, C. D. A., Schalkwijk, C., Kohler, S., Beekman, M., Slagboom, P. E., Wolters, F. J., Ikram, M. A., Vallerga, C. L., van Meurs, J. B. J., Ghanbari, M., ... NCDC Consortium (2024). Biomarkers of endothelial dysfunction and cognition: A two-step IPD meta-analysis. Alzheimer's & Dementia, 20(12), 8402-8411. https://doi.org/10.1002/alz.14272
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  • Huque, M. H., Kootar, S., Kiely, K. M., Anderson, C. S., van Boxtel, M., Brodaty, H., Sachdev, P. S., Carlson, M., Fitzpatrick, A. L., Whitmer, R. A., Kivipelto, M., Jorm, L., Kohler, S., Lautenschlager, N. T., Lopez, O. L., Shaw, J. E., Matthews, F. E., Peters, R., & Anstey, K. J. (2024). A single risk assessment for the most common diseases of ageing, developed and validated on 10 cohort studies. BMC Medicine, 22(1), Article 501. https://doi.org/10.1186/s12916-024-03711-6
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  • Soeterboek, J., Deckers, K., van Boxtel, M. P. J., Backes, W. H., Eussen, S. J. P. M., van Greevenbroek, M. M. J., Jansen, J. F. A., Koster, A., Schram, M. T., Stehouwer, C. D. A., Wesselius, A., Lakerveld, J., Bosma, H., & Köhler, S. (2024). Association of ambient air pollution with cognitive functioning and markers of structural brain damage: The Maastricht study. Environment International, 192, Article 109048. https://doi.org/10.1016/j.envint.2024.109048
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  • Aunsmo, R. H., Strand, B. H., Anstey, K. J., Bergh, S., Kivimaki, M., Kohler, S., Krokstad, S., Livingston, G., Matthews, F. E., & Selbaek, G. (2024). Associations between depression and anxiety in midlife and dementia more than 30 years later: The HUNT Study. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 16(4), Article e70036. https://doi.org/10.1002/dad2.70036
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