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Sebastian Köhler (S.)

Research projects
  • Main applicant and PI Lifestyle Intervention at the Memory Clinic of General and Peripheral Hospitals Trial (LIGHT)
  • Main applicant and Co-PI Netherlands Dementia Prevention Initiative (NDPI)
  • Main applicant and Co-PI Netherlands Dementia Prevention Initiative (NDPI)
  • Work Package risk reduction in a memory clinic population as part of the national ABOARD consortium (www.aboard-project.nl)
  • Co-PI Finger-NL lifestyle intervention trial as part of the national MOCIA consortium (www.mocia.nl)
  • MijnBreincoach app for knowledge transfer on lifestyle and brain health (www.mijnbreincoach.eu)
  • Public health campaign to promote a brain-healthy lifestyle (www.wezijnzelfhetmedicijn.nl)
  • Validation studies of the Lifestyle for Brain Health (LIBRA) index (https://www.alzheimercentrumlimburg.nl/2013-mindd)
  • Management Board Member of The Maastricht Study (www.demaastrichtstudie.nl)
  • PI Maastricht Aging Study (MAAS) into risk factors for cognitive decline in the general population (http://breinweb.nl/maas/)
  • PI CASPER study into cognitive and neuropsychiatric symptoms after stroke (https://www.alzheimercentrumlimburg.nl/2013-casper)
Recent publications
  • Soeterboek, J., Deckers, K., Backes, W. H., Jansen, J. F. A., Schram, M. T., Bosma, H., Lakerveld, J., & Kohler, S. (2025). A cross-sectional study on the association between environmental residential noise exposure with cognitive functioning and structural markers of brain damage-The Maastricht study. Environment International, 206, Article 109932. https://doi.org/10.1016/j.envint.2025.109932
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  • Okoro, C., Zhou, T. L., van der Kallen, C. J. H., Kohler, S., Schram, M. T., & Kroon, A. A. (2025). Lower heart rate variability is associated with worse memory function: The Maastricht Study. Journal of Alzheimer's Disease, 108(4), 1738-1748. https://doi.org/10.1177/13872877251389985
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  • Rosenau, C., Neuffer, J., Kohler, S., Helmer, C., Le Grand, Q., Mishra, A., Debette, S., Tregouet, D.-A., Deckers, K., & Samieri, C. (2025). Updated LIfestyle for BRAin health (LIBRA2) Score, Genetics, and Risk of Alzheimer Disease, Vascular Dementia, and Stroke in Older Adults. Neurology, 105(10), Article e214312. https://doi.org/10.1212/WNL.0000000000214312
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  • Beers, S., de van der Schueren, M. A. E., Grootswagers, P., van de Rest, O., Waterink, L., Sikkes, S. A. M., Deckers, K., Soons, L. M., Claassen, J. A. H. R., Smidt, N., van der Flier, W. M., Köhler, S., Aarts, E., Vermeiren, Y., & de Groot, L. CPGM. (2025). The association between the MIND-NL diet, Dutch dietary guidelines, and global cognitive function in an older population at risk for cognitive decline. Journal of Nutrition Health & Aging, 29(11), Article 100680. https://doi.org/10.1016/j.jnha.2025.100680
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  • van der Heide, F. C. T., Steens, I. L. M., Singh-Manoux, A., Sabia, S., Zhou, T. L., Kohler, S., Schram, M. T., van der Kallen, C. J. H., Berendschot, T. T. J. M., Webers, C. A. B., van Greevenbroek, M. M. J., Wesselius, A., Arts, I. C. W., Jansen, J. F. A., Backes, W. H., van Sloten, T. T., Blokland, G. A. M., & Stehouwer, C. D. A. (2025). Genetic variation in the glucagon-like peptide-1 receptor protein encoding region is associated with higher heart rate variability, but not with neurodegeneration of the brain, retina, and peripheral nerves: The Maastricht study. Cardiovascular Diabetology, 24(1), Article 397. https://doi.org/10.1186/s12933-025-02888-1
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  • Paauw, D., Heger, I., Horstkötter, D., Köhler, S., & Deckers, K. (2025). Awareness and knowledge of dementia risk reduction among current and future health professionals: A survey study. Alzheimer's & Dementia, 21(10), Article e70781. https://doi.org/10.1002/alz.70781
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  • Aunsmo, R. H., Strand, B. H., Bergh, S., Hansen, T., Kivimaki, M., Kohler, S., Krokstad, S., Langballe, E. M., Livingston, G., Matthews, F. E., & Selbaek, G. (2025). Loneliness trajectories and dementia risk: Insights from the HUNT cohort study. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 17(3), Article e70154. https://doi.org/10.1002/dad2.70154
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  • van Baal, T. L., Köhler, S., Koster, A., Meertens, R. M., Bosma, H., Schram, M. T., Jansen, J. F. A., Simons, S. O., de Galan, B. E., Eussen, S. J. P. M., Janssen, N., & Deckers, K. (2025). The association between sleep parameters, cognitive functioning, and markers of brain morphology: The Maastricht Study. Sleep, Article zsaf218. https://doi.org/10.1093/sleep/zsaf218
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  • Bakker, L., Ramakers, I. H. G. B., Greevenbroek, M. M. J. V., Backes, W. H., Jansen, J. F. A., Schram, M. T., Kallen, C. J. H. V. D., Schalkwijk, C. G., Wesselius, A., Ulvik, A., Ueland, P. M., Verhey, F. R. J., Eussen, S. J. P. M., & Kohler, S. (2025). The kynurenine pathway and markers of neurodegeneration and cerebral small vessel disease: The Maastricht Study. Journal of the Neurological Sciences, 474, Article 123522. https://doi.org/10.1016/j.jns.2025.123522
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  • Wesenhagen, K., Deckers, K., Picavet, H., Rietman, M. L., Kok, A., Köhler, S., Ikram, M. A., Wolters, F. J., Huisman, M., & Verschuren, W. (2025). Lifestyle and cognition: Separating the effects of average lifestyle and lifestyle changes based on the LIBRA score. JPAD-Journal of prevention of alzheimers disease, 12(6), Article 100159. https://doi.org/10.1016/j.tjpad.2025.100159
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